New combo therapy for advanced cancers shows early promise in safety trial
NCT ID NCT04420884
First seen Apr 19, 2026 · Last updated May 09, 2026 · Updated 5 times
Summary
This study tested a new drug called TAK-676, alone or with pembrolizumab, in 248 adults with advanced solid tumors that had no standard treatment options. The main goal was to find safe doses and check for side effects. The study did not aim to cure the cancer, but to control the disease and manage symptoms.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Barbara Ann Karmanos Cancer Institute - Lawrence and Idell Weisberg Cancer Treatment Center
Detroit, Michigan, 48201, United States
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Beijing Cancer Hospital
Beijing, Beijing Sheng, 100142, China
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Centre Georges Francois Leclerc
Dijon, 21079, France
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Centre Hospitalier Regional et Universitaire de Besancon - Hopital Jean-Minjoz
Besançon, 25000, France
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Centre Hospitalier Universitaire Vaudois Lausanne
Lausanne, 1011, Switzerland
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Centre Leon Berard
Lyon, 69008, France
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Centre de Lutte contre le Cancer - Centre Oscar Lambret
Lille, 59000, France
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Fox Chase Cancer Center
Philadelphia, Pennsylvania, 19111, United States
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Fudan University Shanghai Cancer Center
Shanghai, Shanghai Municipality, 200025, China
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Gustave Roussy
Villejuif, 94805, France
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Hadassah University Hospital Ein Kerem
Jerusalem, 9112001, Israel
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Hopital Foch
Suresnes, Île-de-France Region, 92150, France
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Hopital Saint-Andre
Bordeaux, 33000, France
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Hopital Saint-Antoine
Paris, 75012, France
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Hopital de la Timone
Marseille, 13385, France
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Hopitaux Universitaires de Geneve
Geneva, 1205, Switzerland
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Inselspital Universitatsspital Bern
Bern, 3010, Switzerland
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Institut de Cancerologie de lOuest - Saint-Herblain - Site Rene Gauducheau
Saint-Herblain, 44805, France
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Jewish General Hospital
Montreal, Quebec, H3T 1E2, Canada
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Kantonsspital Sankt Gallen
Sankt Gallen, Canton of St. Gallen, 9007, Switzerland
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Klinikum Wels-Grieskirchen
Wels, Upper Austria, 4600, Austria
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Leeds Teaching Hospitals NHS Trust
Leeds, LS9 7TF, United Kingdom
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Mary Crowley Cancer Research
Dallas, Texas, 75230, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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McGill University Health Centre
Montreal, Quebec, H4A 3J1, Canada
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Memorial Cancer Institute at Memorial Hospital West - Cancer Institute/Radiology Oncology
Gainesville, Florida, 32610, United States
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Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy
Warsaw, Masovian Voivodeship, 02-034, Poland
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National Cancer Center Hospital
Chuo-Ku, Tokyo, 104-0045, Japan
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Norris Comprehensive Cancer Center
Los Angeles, California, 90089-1019, United States
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Oxford University Hospitals NHS Foundation Trust
Oxford, Ox1 2JD, United Kingdom
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PanOncology Trials: Universidad de Puerto Rico - Centro Comprensivo de Cancer
San Juan, 00936, Puerto Rico
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Princess Margaret Cancer Centre
Toronto, Ontario, M5G 2M9, Canada
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Providence Portland Medical Center
Portland, Oregon, 97213, United States
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Queen's University Belfast
Belfast, Northern Ireland, BT9 7BL, United Kingdom
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Robert H. Lurie Comprehensive Cancer Center of Northwestern University
Chicago, Illinois, 60611, United States
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SCRI - HealthOne Denver
Denver, Colorado, 80218-1238, United States
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Sarah Cannon Research Institute (SCRI)
Nashville, Tennessee, 37203, United States
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Shanghai East Hospital
Shanghai, Shanghai Municipality, 200123, China
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Siteman Cancer Center - North County
Florissant, Missouri, 63031, United States
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Siteman Cancer Center - South County
St Louis, Missouri, 63129, United States
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Siteman Cancer Center - St. Peters
City of Saint Peters, Missouri, 63376, United States
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Siteman Cancer Center - West County
Creve Coeur, Missouri, 63141, United States
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Sixth Affiliated Hospital of Sun Yat-Sen University/Guangdong Gastrointestinal Hospital
Guangzhou, Guangzhou Sheng, 510655, China
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Soroka Medical Center
Beersheba, 9457108, Israel
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Tel Aviv Sourasky Medical Center
Tel Aviv, 64239, Israel
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The Chaim Sheba Medical Center
Tel Litwinsky, 52621, Israel
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UCI Health - Chao Family Comprehensive Cancer Center
Orange, California, 92868, United States
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University College London Hospitals NHS Foundation Trust
London, NW1 2BU, United Kingdom
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University of California Los Angeles - Jonsson Comprehensive Cancer Center
Santa Monica, California, 90404-2023, United States
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University of California San Diego Moores Cancer Center
La Jolla, California, 92093, United States
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University of Cincinnati Health Barrett Cancer Center
Cincinnati, Ohio, 45019, United States
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University of Cincinnati Health Barrett Cancer Center
Cincinnati, Ohio, 45219-2354, United States
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University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center
Baltimore, Maryland, 21201, United States
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University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center
Pittsburgh, Pennsylvania, 15232, United States
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Virginia Cancer Specialists, P.C. - Fairfax
Fairfax, Virginia, 22031-2171, United States
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Washington University School of Medicine Siteman Cancer Center
St Louis, Missouri, 63110-1032, United States
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West Chester Hospital
West Chester, Ohio, 45069, United States
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West China Hospital
Chengdu, Sichuan, 610041, China
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West China School of Medicine - West China Hospital of Sichuan University
Chengdu, Sichuan, 610610, China
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Yale Cancer Center
New Haven, Connecticut, 06519, United States
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Zhejiang Cancer Hospital
Hangzhou, Zhejiang, 310022, China
Conditions
Explore the condition pages connected to this study.