New combo therapy for advanced cancers shows early promise in safety trial

NCT ID NCT04420884

First seen Apr 19, 2026 · Last updated May 09, 2026 · Updated 5 times

Summary

This study tested a new drug called TAK-676, alone or with pembrolizumab, in 248 adults with advanced solid tumors that had no standard treatment options. The main goal was to find safe doses and check for side effects. The study did not aim to cure the cancer, but to control the disease and manage symptoms.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Barbara Ann Karmanos Cancer Institute - Lawrence and Idell Weisberg Cancer Treatment Center

    Detroit, Michigan, 48201, United States

  • Beijing Cancer Hospital

    Beijing, Beijing Sheng, 100142, China

  • Centre Georges Francois Leclerc

    Dijon, 21079, France

  • Centre Hospitalier Regional et Universitaire de Besancon - Hopital Jean-Minjoz

    Besançon, 25000, France

  • Centre Hospitalier Universitaire Vaudois Lausanne

    Lausanne, 1011, Switzerland

  • Centre Leon Berard

    Lyon, 69008, France

  • Centre de Lutte contre le Cancer - Centre Oscar Lambret

    Lille, 59000, France

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Fox Chase Cancer Center

    Philadelphia, Pennsylvania, 19111, United States

  • Fudan University Shanghai Cancer Center

    Shanghai, Shanghai Municipality, 200025, China

  • Gustave Roussy

    Villejuif, 94805, France

  • Hadassah University Hospital Ein Kerem

    Jerusalem, 9112001, Israel

  • Hopital Foch

    Suresnes, Île-de-France Region, 92150, France

  • Hopital Saint-Andre

    Bordeaux, 33000, France

  • Hopital Saint-Antoine

    Paris, 75012, France

  • Hopital de la Timone

    Marseille, 13385, France

  • Hopitaux Universitaires de Geneve

    Geneva, 1205, Switzerland

  • Inselspital Universitatsspital Bern

    Bern, 3010, Switzerland

  • Institut de Cancerologie de lOuest - Saint-Herblain - Site Rene Gauducheau

    Saint-Herblain, 44805, France

  • Jewish General Hospital

    Montreal, Quebec, H3T 1E2, Canada

  • Kantonsspital Sankt Gallen

    Sankt Gallen, Canton of St. Gallen, 9007, Switzerland

  • Klinikum Wels-Grieskirchen

    Wels, Upper Austria, 4600, Austria

  • Leeds Teaching Hospitals NHS Trust

    Leeds, LS9 7TF, United Kingdom

  • Mary Crowley Cancer Research

    Dallas, Texas, 75230, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • McGill University Health Centre

    Montreal, Quebec, H4A 3J1, Canada

  • Memorial Cancer Institute at Memorial Hospital West - Cancer Institute/Radiology Oncology

    Gainesville, Florida, 32610, United States

  • Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy

    Warsaw, Masovian Voivodeship, 02-034, Poland

  • National Cancer Center Hospital

    Chuo-Ku, Tokyo, 104-0045, Japan

  • Norris Comprehensive Cancer Center

    Los Angeles, California, 90089-1019, United States

  • Oxford University Hospitals NHS Foundation Trust

    Oxford, Ox1 2JD, United Kingdom

  • PanOncology Trials: Universidad de Puerto Rico - Centro Comprensivo de Cancer

    San Juan, 00936, Puerto Rico

  • Princess Margaret Cancer Centre

    Toronto, Ontario, M5G 2M9, Canada

  • Providence Portland Medical Center

    Portland, Oregon, 97213, United States

  • Queen's University Belfast

    Belfast, Northern Ireland, BT9 7BL, United Kingdom

  • Robert H. Lurie Comprehensive Cancer Center of Northwestern University

    Chicago, Illinois, 60611, United States

  • SCRI - HealthOne Denver

    Denver, Colorado, 80218-1238, United States

  • Sarah Cannon Research Institute (SCRI)

    Nashville, Tennessee, 37203, United States

  • Shanghai East Hospital

    Shanghai, Shanghai Municipality, 200123, China

  • Siteman Cancer Center - North County

    Florissant, Missouri, 63031, United States

  • Siteman Cancer Center - South County

    St Louis, Missouri, 63129, United States

  • Siteman Cancer Center - St. Peters

    City of Saint Peters, Missouri, 63376, United States

  • Siteman Cancer Center - West County

    Creve Coeur, Missouri, 63141, United States

  • Sixth Affiliated Hospital of Sun Yat-Sen University/Guangdong Gastrointestinal Hospital

    Guangzhou, Guangzhou Sheng, 510655, China

  • Soroka Medical Center

    Beersheba, 9457108, Israel

  • Tel Aviv Sourasky Medical Center

    Tel Aviv, 64239, Israel

  • The Chaim Sheba Medical Center

    Tel Litwinsky, 52621, Israel

  • UCI Health - Chao Family Comprehensive Cancer Center

    Orange, California, 92868, United States

  • University College London Hospitals NHS Foundation Trust

    London, NW1 2BU, United Kingdom

  • University of California Los Angeles - Jonsson Comprehensive Cancer Center

    Santa Monica, California, 90404-2023, United States

  • University of California San Diego Moores Cancer Center

    La Jolla, California, 92093, United States

  • University of Cincinnati Health Barrett Cancer Center

    Cincinnati, Ohio, 45019, United States

  • University of Cincinnati Health Barrett Cancer Center

    Cincinnati, Ohio, 45219-2354, United States

  • University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center

    Baltimore, Maryland, 21201, United States

  • University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center

    Pittsburgh, Pennsylvania, 15232, United States

  • Virginia Cancer Specialists, P.C. - Fairfax

    Fairfax, Virginia, 22031-2171, United States

  • Washington University School of Medicine Siteman Cancer Center

    St Louis, Missouri, 63110-1032, United States

  • West Chester Hospital

    West Chester, Ohio, 45069, United States

  • West China Hospital

    Chengdu, Sichuan, 610041, China

  • West China School of Medicine - West China Hospital of Sichuan University

    Chengdu, Sichuan, 610610, China

  • Yale Cancer Center

    New Haven, Connecticut, 06519, United States

  • Zhejiang Cancer Hospital

    Hangzhou, Zhejiang, 310022, China

Conditions

Explore the condition pages connected to this study.