New hope for advanced cancer: experimental drug HMPL-A580 enters human trials

NCT ID NCT07396584

Recruiting now Disease control Sponsor: Hutchmed Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase trial tests an experimental drug called HMPL-A580 in 186 adults with advanced or metastatic solid tumors that cannot be removed by surgery. The study aims to find a safe dose and check for early signs that the drug shrinks tumors. It is currently recruiting participants.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: HMPL-A580 (an experimental drug)
What this could lead to: If it works, this could point toward a new treatment option for people with advanced solid tumors that have not responded to other therapies.
What could go wrong: This is an early, first-in-human trial, so the drug may not be effective or could cause unexpected side effects. Results are preliminary and may not lead to a widely available treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

metastatic malignant neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SOLID TUMORS, ADULT

Contacts and locations

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Locations

BRCR Global
NOT_YET_RECRUITING

Plantation, Florida, 33324, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Florida Clinical Trials Group LLC (Plantation)
NOT_YET_RECRUITING

Plantation, Florida, 33324, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Florida Clinical Trials Group LLC (Tamarac)
NOT_YET_RECRUITING

Tamarac, Florida, 33319, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Guangxi Medical University Cancer Hospital
NOT_YET_RECRUITING

Nanning, China

Contact
Henan Cancer Hospital
NOT_YET_RECRUITING

Zhengzhou, China

Contact
Hunan Cancer Hospital
NOT_YET_RECRUITING

Changsha, China

Contact
Shanghai East Hospital
RECRUITING

Shanghai, China

Contact Phone: •••-•••-•••• Email: •••••@•••••
The First Affiliated Hospital of Xiamen University
NOT_YET_RECRUITING

Xiamen, China

Contact
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
NOT_YET_RECRUITING

Wuhan, China

Contact
University of California Irvine Medical Center
NOT_YET_RECRUITING

Orange, California, 92868, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Washington/Fred Hutchinson Cancer Center
NOT_YET_RECRUITING

Seattle, Washington, 98109, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

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