New hope for Hard-to-Treat cancers: drug targets MTAP deletion
NCT ID NCT07492680
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests a drug called BMS-986504 in people with advanced solid tumors that have lost a gene called MTAP. The drug is given alone or with other cancer medicines. The study aims to see if the drug shrinks tumors and how safe it is. About 260 adults will take part.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
BMS-986504 (also called MRTX1719 or Navlimetostat)
What this could lead to
If successful, this could lead to a new treatment option for people with advanced solid tumors that have a specific genetic deletion (MTAP).
What could go wrong
This is an early phase 2 trial, so the drug may not work or may cause side effects. It is only for people with a specific tumor marker, so it won't apply to most cancer patients.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Locations
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Local Institution - 0004
Seoul, Seoul-teukbyeolsi [Seoul], 03080, South Korea
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Local Institution - 0007
Toronto, Ontario, M5G 2M9, Canada
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Local Institution - 0020
Chuo-ku, Tokyo, 104-0045, Japan
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Local Institution - 0021
Toronto, Ontario, M4N 3M5, Canada
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Local Institution - 0022
Oslo, 0450, Norway
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Local Institution - 0023
Dublin, 7, Ireland
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Local Institution - 0033
Madrid, 28028, Spain
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Local Institution - 0034
Milan, 20133, Italy
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Local Institution - 0039
Heidelberg, 69120, Germany
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Local Institution - 0040
Hamburg, 20246, Germany
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Local Institution - 0047
Würzburg, 97080, Germany
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Local Institution - 0049
München, 81675, Germany
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Local Institution - 0050
Naples, 80131, Italy
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Local Institution - 0051
Vancouver, British Columbia, V2S 0C2, Canada
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Local Institution - 0052
Seoul, Seoul-teukbyeolsi [Seoul], 05505, South Korea
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Local Institution - 0058
Seoul, Seoul-teukbyeolsi [Seoul], 03722, South Korea
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Local Institution - 0059
Madrid, Madrid, Comunidad de, 28034, Spain
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Local Institution - 0061
Leipzig, 04103, Germany
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Local Institution - 0063
Shatin, NT, Hong Kong
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Local Institution - 0068
Barcelona, Barcelona [Barcelona], 08035, Spain
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Local Institution - 0069
Seville, 41013, Spain
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Local Institution - 0071
Hospitalet, Barcelona [Barcelona], 08907, Spain
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Local Institution - 0073
Siena, Tuscany, 53100, Italy
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Local Institution - 0074
Paris, 75010, France
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Local Institution - 0075
Pierre-Bénite, Rhône, 69310, France
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Local Institution - 0078
Dijon, Côte-d'Or, 21079, France
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Local Institution - 0080
Cork, T12 E8YV, Ireland
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Local Institution - 0081
Mainz, Rhineland-Palatinate, 55131, Germany
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Local Institution - 0082
Perugia, 06156, Italy
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Local Institution - 0085
Houston, Texas, 77030, United States
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Local Institution - 0086
Seattle, Washington, 98109, United States
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Local Institution - 0096
San Francisco, California, 94158, United States
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Local Institution - 0100
Durham, North Carolina, 27705, United States
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Local Institution - 0106
Chicago, Illinois, 60637, United States
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Local Institution - 0114
Ghent, Oost-Vlaanderen, 9000, Belgium
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Local Institution - 0116
Villejuif, Val-de-Marne, 94800, France
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Local Institution - 0119
Ann Arbor, Michigan, 48109-0922, United States
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Local Institution - 0122
Tampa, Florida, 33612, United States
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Local Institution - 0123
Bergamo, 24127, Italy
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Local Institution - 0124
Boston, Massachusetts, 02114, United States
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Local Institution - 0129
Rochester, Minnesota, 55905, United States
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Local Institution - 0134
Madison, Wisconsin, 53792, United States
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Local Institution - 0139
New York, New York, 10065, United States
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Local Institution - 0142
Buffalo, New York, 14263, United States
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Local Institution - 0143
Baltimore, Maryland, 21287, United States
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Local Institution - 0146
Dublin, D08 E9P6, Ireland
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Local Institution - 0150
Hksar, 999077, Hong Kong
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Local Institution - 0153
Shanghai, Shanghai Municipality, 200032, China
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Local Institution - 0155
Beijing, Beijing Municipality, 100071, China
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Local Institution - 0156
Shanghai, Shanghai Municipality, 200131, China
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Local Institution - 0170
New York, New York, 10016, United States
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Local Institution - 0171
Bergen, Hordaland, 5021, Norway
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Local Institution - 0174
Rochester, Minnesota, 55905, United States
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Local Institution - 0178
Atlanta, Georgia, 30322, United States
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Local Institution - 0181
Rochester, Minnesota, 55905, United States
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Local Institution - 0182
Aurora, Colorado, 80045, United States
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Local Institution - 0184
Guangzhou, Guangdong, 510060, China
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Local Institution - 0185
Chongqing, Chongqing Municipality, 400030, China
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