New vaccine combo aims to rally immune system against advanced head and neck cancer

NCT ID NCT06868433

First seen Mar 15, 2026 · Last updated Apr 28, 2026 · Updated 5 times

Summary

This early-phase trial tests a personalized vaccine made from a patient's own tumor cells, given alone or with the immunotherapy drug pembrolizumab, for head and neck cancer that has returned or spread. The study aims to find the safest dose and check for side effects in about 40 adults. The vaccine is designed to train the immune system to attack the cancer, while pembrolizumab helps remove cancer's shields.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Emory University Hospital Midtown

    RECRUITING

    Atlanta, Georgia, 30308, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Emory University Hospital/Winship Cancer Institute

    RECRUITING

    Atlanta, Georgia, 30322, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.

CLINICAL STAGE IV HPV-MEDIATED (P16-POSITIVE) OROPHARYNGEAL CARCINOMA AJCC V8 CLINICAL STAGE IV HPV-MEDIATED (P16-POSITIVE) OROPHARYNGEAL CARCINOMA AJCC V8 METASTATIC HEAD AND NECK SQUAMOUS CELL CARCINOMA METASTATIC HYPOPHARYNGEAL SQUAMOUS CELL CARCINOMA METASTATIC LARYNGEAL SQUAMOUS CELL CARCINOMA METASTATIC NASOPHARYNGEAL SQUAMOUS CELL CARCINOMA METASTATIC ORAL CAVITY SQUAMOUS CELL CARCINOMA METASTATIC ORAL CAVITY SQUAMOUS CELL CARCINOMA METASTATIC OROPHARYNGEAL SQUAMOUS CELL CARCINOMA METASTATIC SINONASAL SQUAMOUS CELL CARCINOMA RECURRENT HEAD AND NECK SQUAMOUS CELL CARCINOMA RECURRENT HYPOPHARYNGEAL SQUAMOUS CELL CARCINOMA RECURRENT LARYNGEAL SQUAMOUS CELL CARCINOMA RECURRENT NASOPHARYNGEAL SQUAMOUS CELL CARCINOMA RECURRENT ORAL CAVITY SQUAMOUS CELL CARCINOMA RECURRENT ORAL CAVITY SQUAMOUS CELL CARCINOMA RECURRENT OROPHARYNGEAL SQUAMOUS CELL CARCINOMA RECURRENT OROPHARYNGEAL SQUAMOUS CELL CARCINOMA RECURRENT SINONASAL SQUAMOUS CELL CARCINOMA SQUAMOUS CELL CARCINOMA OF UNKNOWN PRIMARY STAGE IV CUTANEOUS SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK AJCC V8 STAGE IV HYPOPHARYNGEAL CARCINOMA AJCC V8 STAGE IV HYPOPHARYNGEAL CARCINOMA AJCC V8 STAGE IV LARYNGEAL CANCER AJCC V8 STAGE IV LARYNGEAL CANCER AJCC V8 STAGE IV LIP AND ORAL CAVITY CANCER AJCC V8 STAGE IV LIP AND ORAL CAVITY CANCER AJCC V8 STAGE IV NASOPHARYNGEAL CARCINOMA AJCC V8 STAGE IV NASOPHARYNGEAL CARCINOMA AJCC V8 STAGE IV OROPHARYNGEAL (P16-NEGATIVE) CARCINOMA AJCC V8 STAGE IV OROPHARYNGEAL (P16-NEGATIVE) CARCINOMA AJCC V8 STAGE IV SINONASAL CANCER AJCC V8 STAGE IV SINONASAL CANCER AJCC V8