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Blood test vs. scalpel: could liquid biopsy replace tissue biopsies for cancer monitoring?

NCT ID NCT05245136

Recruiting now Knowledge-focused Sponsor: University Hospital Augsburg Source: ClinicalTrials.gov ↗

First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This large observational study is testing whether a blood-based 'liquid biopsy' can detect tumor mutations and track disease progression in people with metastatic or advanced solid tumors who are receiving palliative care. Researchers will compare results from liquid biopsies with standard tissue biopsies to see how well they match. The goal is to understand if liquid biopsy can serve as a reliable, less invasive tool for diagnosis and monitoring.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this could show that a simple blood test (liquid biopsy) can reliably detect cancer mutations and monitor disease progression, potentially reducing the need for invasive tissue biopsies.
What could go wrong
This is an observational study, not a treatment trial, so it won't directly improve outcomes. Liquid biopsy may not be accurate enough to replace tissue biopsy in all cases.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

disease characteristic metastatic malignant neoplasm neoplasm Neoplasm Metastasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHARACTERISTICS DISEASE METASTATIC CANCER SOLID TUMOR

Contacts and locations

Locations

  • University Hospital Augsburg

    RECRUITING

    Augsburg, Bavaria, 86156, Germany

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