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Heart drug could boost radiation for brain tumors in lung cancer patients

NCT ID NCT06238882

Recruiting now Disease control Sponsor: Instituto Nacional de Cancerologia de Mexico Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This phase III trial tests whether adding nitroglycerin patches to standard radiation therapy helps shrink brain tumors better than radiation alone in people with a specific type of lung cancer (EGFR-mutant non-small cell lung cancer). 74 participants will receive either radiation plus nitroglycerin or radiation alone. The study will measure tumor response, survival, quality of life, and side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
nitroglycerin patch
What this could lead to
If it works, this could improve how well radiation shrinks brain tumors in people with a specific type of lung cancer, potentially extending life and preserving brain function.
What could go wrong
This is a small, early-stage trial (74 people) testing a repurposed drug. Nitroglycerin can cause headaches and low blood pressure, and the added benefit over radiation alone is uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain cancer metastatic malignant neoplasm in the brain non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN METASTASES EGFR GENE MUTATION NON-SMALL CELL LUNG CANCER

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Instituto Nacional de Cancerologia

    RECRUITING

    Mexico City, Mexico City, 14080, Mexico

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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