Could a tiny dose of radiation ease myeloma bone pain?

NCT ID NCT03858205

Recruiting now Symptom relief Sponsor: University of Southern California Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a very low dose of radiation (2 Gy) can relieve bone pain in people with multiple myeloma that has spread to the bones. The goal is to see if this gentler approach works as well as standard radiation but with fewer side effects and less disruption to chemotherapy schedules. About 100 participants will report their pain levels and quality of life before and after treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: low-dose radiation therapy
What this could lead to: If it works, this could offer a gentler, more convenient way to relieve bone pain in multiple myeloma patients, with fewer side effects and less interference with chemotherapy.
What could go wrong: This is a mid-stage trial with only 100 participants, so results may not apply to everyone. Pain relief may be modest or short-lived, and some side effects from radiation are still possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for BONE PAIN are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

metastatic carcinoma in the bone plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BONE PAIN METASTATIC MALIGNANT NEOPLASM IN THE BONE PLASMA CELL MYELOMA

Contacts and locations

Locations

Cedars Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States
City of Hope
RECRUITING

Duarte, California, 91010, United States
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Emory University Hospital/Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30322, United States
Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States
Los Angeles General Medical Center
RECRUITING

Los Angeles, California, 90033, United States
USC / Norris Comprehensive Cancer Center
RECRUITING

Los Angeles, California, 90033, United States
University of Minnesota - Masonic Cancer Center
RECRUITING

Minneapolis, Minnesota, 55455, United States
University of Pennsylvania/Abramson Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.