Could a blood chemical explain bone pain in breast cancer?
NCT ID NCT03529565
First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time
Summary
This study looks at whether levels of histamine, a chemical in the blood, are linked to bone pain in people with breast cancer that has spread to the bones. Researchers will collect blood samples from participants and compare histamine levels with pain scores, including in those who have or haven't had palliative radiotherapy. The goal is to better understand the causes of cancer bone pain and potentially find new ways to reduce it or prevent further spread.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Blood sample collection for laboratory analysis
- What this could lead to
- If a link is found, it could point toward new ways to manage bone pain or slow bone metastasis in breast cancer.
- What could go wrong
- This is a small observational study, so any findings may not apply broadly. It does not test a treatment, so it cannot directly improve pain or outcomes.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157, United States
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