Can a cancer drug's real-world performance match clinical trial results?

NCT ID NCT04458831

Completed Disease control Sponsor: Sanofi Source: ClinicalTrials.gov ↗

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

This study tracks adults with relapsed or refractory multiple myeloma who are already receiving isatuximab as part of their routine care. Researchers will measure how many patients respond to treatment, how long the response lasts, and how the drug affects quality of life and side effects. The goal is to see if the benefits seen in earlier trials hold up in a broader, more diverse patient population.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: isatuximab (Sarclisa), often combined with pomalidomide, dexamethasone, or carfilzomib
What this could lead to: If the results are positive, this could confirm that isatuximab is effective and safe for treating multiple myeloma in real-world settings, beyond controlled trials.
What could go wrong: This is an observational study, not a controlled experiment, so it cannot prove cause and effect. Results may be influenced by patient selection and other treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PLASMA CELL MYELOMA

Contacts and locations

Locations

AMR Kansas City Site Number : 8400016

Kansas City, Missouri, 64114, United States
AZ Nikolaas - Investigational Site Number : 0560002

Sint-Niklaas, 9100, Belgium
Albert Schweitzer Ziekenhuis - Investigational Site Number : 5820001

Dordrecht, 3318 AT, Netherlands
Auxilio Mutuo Cancer Center Site Number : 8400029

San Juan, 00917, Puerto Rico
Azienda Ospedaliera Universitaria "Federico II"-Investigational Site Number : 3800001

Naples, 80138, Italy
Azienda Ospedaliera Universitaria Policlinico Umberto I - Investigational Site Number : 3800002

Rome, Roma, 00137, Italy
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia - Investigational Site Number : 3800007

Brescia, 25123, Italy
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia - Investigational Site Number : 3800009

Rome, Roma, 00133, Italy
CHU Poitiers - Hôpital la Milétrie - Investigational Site Number : 2500008

Poitiers, 86021, France
CHU Reims - Hôpital Robert Debré - Investigational Site Number : 2500010

Reims, 51092, France
Central Care Cancer Center Site Number : 8400006

Garden City, Missouri, 67846, United States
Central Care Cancer Center Site Number : 8400019

Garden City, Kansas, 67846, United States
Central Maine Medical Center Site Number : 8400031

Lewiston, Maine, 04240, United States
Centre Hospitalier Le Mans - Investigational Site Number : 2500015

Le Mans, 72037, France
Centre Hospitalier Metropole Savoie - Investigational Site Number : 2500006

Chambéry, 73000, France
Centre Hospitalier Victor Dupouy - Investigational Site Number : 2500007

Argenteuil, 95107, France
Charleston Hematology Oncology Associates, PA Site Number : 8400020

Charleston, South Carolina, 29414, United States
Clinique Louis Pasteur, Maison Médicale - Investigational Site Number : 2500012

Essey-lès-Nancy, 54270, France
Complejo Asistencial Universitario de Leon Altos de Nava s/n. -Investigational Site Number : 7240005

León, León, 24071, Spain
Complejo Hospitalario Universitario de Pontevedra - Investigational Site Number : 7240011

Pontevedra, 36001, Spain
Comprehensive Hematology Oncology Site Number : 8400026

St. Petersburg, Florida, 33709, United States
Dietrich-Bonhoeffer-Klinikum - Investigational Site Number : 2760044

Neubrandenburg, 17036, Germany
Freeman Hospital - Investigational Site Number : 8260003

Newcastle upon Tyne, NE7 7DN, United Kingdom
GEFOS Gesellschaft f. onkologische Studien -Investigational Site Number : 2760001

Dortmund, 44263, Germany
GenesisCare Site Number : 8400007

Jacksonville, Florida, 32204, United States
Hematology & Oncology Associates Site Number : 8400015

Canton, Ohio, 44708, United States
Holy Cross Hospital Site Number : 8400030

Fort Lauderdale, Florida, 33308, United States
Hospital Regional Universitario de Malaga Hospital Regional Universitario de Malaga - Investigational Site Number : 7240006

Málaga, Málaga, 29010, Spain
Hospital Universitari Son Espases - Investigational Site Number : 7240003

Palma de Mallorca, Balearic Islands, 07120, Spain
Hospital Universitario Virgen de la Nieves - Investigational Site Number : 7240010

Granada, 18012, Spain
Hospital Universitario de Navarra - Investigational Site Number : 7240009

Pamplona, Navarre, 31008, Spain
Huddersfield Royal Infirmary - Investigational Site Number : 8260004

Huddersfield, HD3 3EA, United Kingdom
Institut Jules Bordet - Investigational Site Number : 0560001

Anderlecht, 1070, Belgium
Investigational Site Number : 0320001

Ciudad Autonoma Buenos Aires, Buenos Aires, 1199, Argentina
Investigational Site Number : 0320002

Córdoba, X5016KEH, Argentina
Investigational Site Number : 0320004

Buenos Aires, C1118AAT, Argentina
Investigational Site Number : 0320005

Córdoba, X5000JHQ, Argentina
Investigational Site Number : 0320006

Pilar, Buenos Aires, B1629ODT, Argentina
Investigational Site Number : 1560001

Shenzhen, 518053, China
Investigational Site Number : 1560002

Guangzhou, 510120, China
Investigational Site Number : 1580001

Taipei, 100, Taiwan
Investigational Site Number : 1580002

Kaohsiung City, 833401, Taiwan
Investigational Site Number : 2500001

Rouen, 76038, France
Investigational Site Number : 2500004

Montpellier, 34295, France
Investigational Site Number : 2500005

Saint-Priest-en-Jarez, 42270, France
Investigational Site Number : 2500009

Pessac, 33604, France
Investigational Site Number : 2500011

Vannes, 56017, France
Investigational Site Number : 2500013

Lille, 59800, France
Investigational Site Number : 2500014

Saint-Quentin, 02321, France
Investigational Site Number : 2500016

Tarbes, 65013, France
Investigational Site Number : 2500017

Cahors, 46000, France
Investigational Site Number : 2760002

Dresden, 01127, Germany
Investigational Site Number : 2760003

Berlin, 10117, Germany
Investigational Site Number : 2760006

München, 81241, Germany
Investigational Site Number : 2760007

Donauwörth, 86609, Germany
Investigational Site Number : 2760008

Leipzig, 04289, Germany
Investigational Site Number : 2760012

Hanover, 30449, Germany
Investigational Site Number : 2760013

Herrsching am Ammersee, 82211, Germany
Investigational Site Number : 2760016

Aschaffenburg, 63739, Germany
Investigational Site Number : 2760018

Bayreuth, 95445, Germany
Investigational Site Number : 2760019

Würzburg, 97070, Germany
Investigational Site Number : 2760020

Bamberg, 96052, Germany
Investigational Site Number : 2760021

Oldenburg, 26121, Germany
Investigational Site Number : 2760022

Berlin, 12200, Germany
Investigational Site Number : 2760031

Weilheim, 82362, Germany
Investigational Site Number : 2760035

Dresden, 01307, Germany
Investigational Site Number : 2760036

Oldenburg, 26133, Germany
Investigational Site Number : 2760037

Frankfurt, 60596, Germany
Investigational Site Number : 2760040

Stolberg, 52222, Germany
Investigational Site Number : 2760041

Berlin, 10437, Germany
Investigational Site Number : 3000005

Piraeus, 18537, Greece
Investigational Site Number : 3440001

Hong Kong, Hong Kong
Investigational Site Number : 3800003

Milan, 20132, Italy
Investigational Site Number : 3800004

Trento, 38122, Italy
Investigational Site Number : 3800006

Bari, 70124, Italy
Investigational Site Number : 3800008

Novara, 28100, Italy
Investigational Site Number : 3800010

Treviso, 31100, Italy
Investigational Site Number : 3800013

Pavia, 27100, Italy
Investigational Site Number : 3920001

Yamagata, 990-9585, Japan
Investigational Site Number : 3920003

Sunto-gun, Shizuoka, 411-8777, Japan
Investigational Site Number : 3920004

Minato-ku, Tokyo, 105-8470, Japan
Investigational Site Number : 3920005

Okayama, 701-1192, Japan
Investigational Site Number : 3920008

Shibukawa-shi, 377-0280, Japan
Investigational Site Number : 3920009

Osaka, Osaka, 543-8555, Japan
Investigational Site Number : 3920010

Fukuoka, 815-8555, Japan
Investigational Site Number : 3920011

Suwa-shi, 392-8510, Japan
Investigational Site Number : 3920012

Sapporo, Hokkaido, 003-0006, Japan
Investigational Site Number : 3920013

Minatoku, 105-8471, Japan
Investigational Site Number : 3920014

Osakasayama-shi, 589-8511, Japan
Investigational Site Number : 4140001

Kuwait City, 42262, Kuwait
Investigational Site Number : 5760001

Bern, 3010, Switzerland
Investigational Site Number : 6430006

Volgograd, 400138, Russia
Investigational Site Number : 6820001

Khobar, 34234, Saudi Arabia
Investigational Site Number : 6820002

Riyadh, 11426, Saudi Arabia
Investigational Site Number : 6820004

Jeddah, 23431 6688, Saudi Arabia
Investigational Site Number : 6820005

Jeddah, 21423, Saudi Arabia
Investigational Site Number : 7240004

Toledo, 45003, Spain
Investigational Site Number : 7840001

Abu Dhabi, 7400, United Arab Emirates
Investigational Site Number : 7840002

Abu Dhabi, 11001, United Arab Emirates
Investigational Site Number : 8260002

Nottingham, Nottinghamshire, NG5 1PB, United Kingdom
Investigational Site Number : 8260005

Sutton, Surrey, SM2 5PT, United Kingdom
Istituto di Ematologia e Oncologia Medica - Investigational Site Number : 3800005

Bologna, 40138, Italy
Kantonsspital Baden AG - Investigational Site Number : 5760003

Baden, 5404, Switzerland
Klinikum Ernst von Bergmann gGmbH -Investigational Site Number : 2760039

Potsdam, 14467, Germany
Klinikum Kulmbach mit Fachklinik Stadtsteinach - Investigational Site Number : 2760026

Kulmbach, 95326, Germany
Klinikum Schwaebisch Gmuend - Investigational Site Number : 2760042

Mutlangen, 73557, Germany
LKH Steyr - Investigational Site Number : 0400002

Steyr, 4400, Austria
MD Anderson Cancer Center Site Number : 8400013

Houston, Texas, 77030-4000, United States
MV Zentrum für Onkologie und Hämatologie - Investigational Site Number : 2760034

Cologne, 50677, Germany
Michigan Center of Medical Research Site Number : 8400010

Farmington Hills, Michigan, 48334, United States
Millennium Oncology Site Number : 8400025

Pembroke Pines, Florida, 33024, United States
Novant Health Forsyth Medical Center Site Number : 8400028

Winston-Salem, North Carolina, 27103, United States
Onkologische Gemeinschaftspraxis am Bethanien-Krankenhaus - Investigational Site Number : 2760010

Frankfurt am Main, 60389, Germany
Philipps-Universitat Marburg, Klinic fur Innere Medizin -Investigational Site Number : 2760038

Marburg, 35037, Germany
Prairie Lakes Health Care System, Inc Site Number : 8400002

Watertown, South Dakota, 57201-1548, United States
Praxis am Volkspark - Investigational Site Number : 2760009

Berlin, 10715, Germany
Prisma Health - Eastside Office Site Number : 8400011

Greenville, South Carolina, 29615, United States
Puerto Rico Medical Research Center, LLC Site Number : 8400001

Hato Rey, 00917, Puerto Rico
Regional Cancer Care Associates - Little Silver Division Site Number : 8400018

Little Silver, New Jersey, 07739, United States
Regional Cancer Care Associates Site Number : 8400024

Howell Township, New Jersey, 07731, United States
Regional Cancer Care Associates, LLC - Freehold Division Site Number : 8400017

Freehold, New Jersey, 07728, United States
Renovatio Clinical Site Number : 8400004

The Woodlands, Texas, 77380, United States
St. Joseph Heritage Healthcare Site Number : 8400008

Fullerton, California, 92835, United States
Stadtspital Triemli - Investigational Site Number : 5760002

Zurich, 8063, Switzerland
Tri County Hematology & Oncology Associates, Inc Site Number : 8400012

Massillon, Ohio, 44646, United States
University of Arkansas Medical Sciences Site Number : 8400021

Little Rock, Arkansas, 72205-7199, United States
University of California San Francisco (PARENT) Site Number : 8400009

San Francisco, California, 94143, United States
Watson Clinic Cancer and Research Center Site Number : 8400023

Lakeland, Florida, 33805, United States
omplejo Hospitalario Universitario de Canarias - Investigational Site Number : 7240007

San Cristóbal de La Laguna, 38320, Spain

More trials for these conditions

Other studies related to the condition(s) this trial covers.