New drug targets tumor protein in first human tests

NCT ID NCT07287995

Recruiting now Disease control Sponsor: Astellas Pharma Global Development, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase study tests a new drug, ASP2998, that targets a protein called TROP2 found on many solid tumors. The drug is given alone or with standard treatments like pembrolizumab or carboplatin. The main goals are to check safety and find the right dose. About 428 adults with advanced bladder, lung, stomach, or breast cancers that have not responded to prior therapy may join.

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Conditions

The condition(s) this trial relates to.

breast neoplasm gastric cancer gastroesophageal junction adenocarcinoma Her2-receptor negative breast cancer metastatic malignant neoplasm non-small cell lung carcinoma transitional cell carcinoma urothelial carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALLY ADVANCED OR METASTATIC MALIGNANT SOLID TUMORS

Contacts and locations

Locations

John Theurer Cancer Center at Hackensack University Medical Center
RECRUITING

Hackensack, New Jersey, 07601, United States
NEXT Virginia
RECRUITING

Fairfax, Virginia, 22031, United States
National Cancer Center Hospital
RECRUITING

Chuo-ku, Tokyo, Japan
National Cancer Center Hospital East
RECRUITING

Kashiwa-shi, Chiba, Japan
START New York Long Island
RECRUITING

New Hyde Park, New York, 11042, United States
Tennessee Oncology
RECRUITING

Nashville, Tennessee, 37203, United States
The Cancer Institute Hospital of JFCR
RECRUITING

Koto-ku, Tokyo, Japan

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