Could less radiation be better for some cancers?

NCT ID NCT05010031

Recruiting now Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether a lower dose of radiation can effectively treat metastatic tumors that have a specific genetic change called an ATM mutation. The goal is to find the smallest effective dose to reduce side effects. About 45 adults with advanced cancer and an ATM mutation will receive palliative radiotherapy and be followed for up to 6 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: palliative radiotherapy
What this could lead to: If successful, this could show that lower radiation doses are effective for ATM-mutated tumors, reducing side effects while maintaining tumor control.
What could go wrong: This is a small, early-phase study with only 45 participants, so results may not apply broadly. The reduced dose might not control tumors as well as standard doses.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hereditary sensory and autonomic neuropathy metastatic malignant neoplasm Neoplasm Metastasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC CANCER

Contacts and locations

Locations

Memorial Sloan Kettering Basking Ridge (All Protocol Activities)
RECRUITING

Basking Ridge, New Jersey, 10065, United States
Memorial Sloan Kettering Bergen (All protocol activities)
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Commack (All protocol activities)
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth (All protocol activities)
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau (All protocol activities)
RECRUITING

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester (All Protocol Activities)
RECRUITING

Harrison, New York, 10604, United States

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