New hope for HER2-Low breast cancer: experimental drug takes on market leader
NCT ID NCT07497386
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial is testing a new drug, trastuzumab rezetecan, against an existing drug, trastuzumab deruxtecan, in 150 women with a common type of advanced breast cancer (HR-positive, HER2-low). The goal is to see which dose works best to slow cancer growth. Participants must have already tried hormone therapy without success.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- trastuzumab rezetecan (an antibody-drug conjugate) compared to trastuzumab deruxtecan
- What this could lead to
- If successful, this could provide a new treatment option for people with HR-positive, HER2-low advanced breast cancer who have stopped responding to hormone therapy.
- What could go wrong
- This is a phase 2 trial with only 150 participants, so results are preliminary. The experimental drug may not be more effective or safer than the existing drug, and side effects are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Cancer Hospital, Chinese Academy of Medical Sciences
RECRUITINGBeijing, Beijing Municipality, 100021, China