Could an old drug tame cancer in the spinal fluid? new trial aims to find out

NCT ID NCT05184816

Recruiting now Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 15, 2026 · Updated 2 times

Summary

This early-phase trial tests whether deferoxamine, a drug given directly into the spinal fluid, is safe for people with leptomeningeal metastases—cancer that has spread to the lining of the brain and spinal cord. Researchers will test different doses in 35 adults with solid tumor cancers to find the safest dose and see how the body handles the drug. The goal is to control the disease, not cure it, and participants must be well enough to have a life expectancy of at least 8 weeks.

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Conditions

The condition(s) this trial relates to.

Meningeal Carcinomatosis neoplastic meningitis Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LEPTOMENINGEAL METASTASES

Contacts and locations

Locations

Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)
RECRUITING

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen (Limited Protocol Activities)
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau (Limited Protocol Activities)
RECRUITING

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities)
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Westchester (Limited Protocol Activities)
RECRUITING

Harrison, New York, 10604, United States

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