New hope for advanced colorectal cancer: drug cocktail shows promise

NCT ID NCT07407465

Recruiting now Disease control Sponsor: Gruppo Oncologico del Nord-Ovest Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a combination of three drugs (trastuzumab-deruxtecan, capecitabine, and bevacizumab) as a first treatment for people with HER-2 positive colorectal cancer that has spread or cannot be removed by surgery. The goal is to see how well the drugs shrink tumors. About 42 adults will take part. The approach aims to control the disease, not cure it.

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Conditions

The condition(s) this trial relates to.

colon adenocarcinoma colonic neoplasm colorectal adenocarcinoma colorectal cancer colorectal neoplasm metastatic malignant neoplasm in the colon Neoplasm Metastasis rectal cancer rectal neoplasm rectum adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLON CANCER ADENOCARCINOMA COLON CANCER METASTATIC COLORECTAL ADENOCARCINOMA COLORECTAL CANCER RECTAL ADENOCARCINOMA RECTAL CANCER, ADENOCARCINOMA RECTAL CANCER, METASTATIC

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

A.O.U Careggi
RECRUITING

Florence, Firenze, 50134, Italy
Azienda Ospedaliera Card. G. Panico
RECRUITING

Tricase, LE, 73039, Italy
Azienda Ospedaliera Universitaria Luigi Vanvitelli
RECRUITING

Naples, 80131, Italy
Azienda Ospedaliero Universitaria di Modena
RECRUITING

Modena, Missouri, 41124, Italy
Azienda Sanitaria Universitaria Friuli Centrale
RECRUITING

Udine, Udine, 33100, Italy
Azienda Unita Sanitaria Locale Della Romagna
RECRUITING

Ravenna, Italy, 48121, Italy
Centre Hospitalier Universitaire Reims
RECRUITING

Reims, France
Charite Universitaetsmedizin
RECRUITING

Berlin, Germany
Fondazione IRCCS Istituto Nazionale dei Tumori - Milano
RECRUITING

Milan, Milan, 20133, Italy
Fondazione IRCCS Istituto Oncologico Veneto
RECRUITING

Padova, 35128, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
RECRUITING

Roma, RM, 00168, Italy
Groupe Hospitalier Rance Emeraude
RECRUITING

St-Malo, France
Hopital Prive Jean Mermoz
RECRUITING

Lyon, France
Hopital Saint Louis
RECRUITING

Paris, France
Hospital Clínico Universitario Santiago de Compostela
RECRUITING

Santiago de Compostela, Spain
Hospital Clínico Universitario de Valencia
RECRUITING

Valencia, Spain
Hospital Universitario Fundación Jiménez
RECRUITING

Madrid, Spain
Hospital Universitario Virgen de las Nieves
RECRUITING

Granada, Spain
Hospital del Mar
RECRUITING

Barcelona, Spain
Humanitas Mirasole S.p.A.
RECRUITING

Rozzano, Italy, 20089, Italy
Hôpital La Timone - APHM
RECRUITING

Marseille, France
IFO-Regina Elena Institute for Cancer Research
RECRUITING

Roma, Roma, 00144, Italy
IRCCS Istituto Nazionale Tumori "Fondazione Giovanni Pascale"
RECRUITING

Naples, 80131, Italy
Istituto Europeo Di Oncologia S.r.l.
RECRUITING

Milan, Italy, 20141, Italy
Istituto Tumori Bari Giovanni Paolo II
RECRUITING

Bari, Bari, 70124, Italy
Krankenhaus Nordwest
RECRUITING

Frankfurt, Germany
Policlinico Tor Vergata Roma
RECRUITING

Roma, Roma, 00133, Italy
U.O. Oncologia Medica 2 Universitaria - Azienda Ospedaliero-Universitaria Pisana Dipartimento di Ricerca Traslazionale e Nuove Tecnologie - University of Pisa
RECRUITING

Pisa, 56126, Italy

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