New drug JZP815 targets tough cancers in early trial
NCT ID NCT05557045
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase study is testing a new drug called JZP815 in people with advanced or spreading solid tumors that have specific changes in the MAPK pathway. The main goals are to check the drug's safety, find the right dose, and see if it can shrink tumors. About 332 adults who have run out of standard treatment options will take part.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ADVANCED CANCER are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Florida Cancer Specialists - Lake Nona
RECRUITINGOrlando, Florida, 32827, United States
-
Florida Cancer Specialists - Sarasota
RECRUITINGSarasota, Florida, 34232, United States
-
Icahn School of Medicine at Mount Sinai
RECRUITINGNew York, New York, 10029, United States
-
NYU Langone Health
RECRUITINGNew York, New York, 10016, United States
-
Oklahoma University
RECRUITINGOklahoma City, Oklahoma, 73104, United States
-
SCRI HealthOne
RECRUITINGDenver, Colorado, 80218, United States
-
Sidney Kimmel Cancer Center
RECRUITINGPhiladelphia, Pennsylvania, 19107, United States
-
Tennessee Oncology - Nashville
RECRUITINGNashville, Tennessee, 37203, United States
-
Texas Oncology- Central South
RECRUITINGAustin, Texas, 78731, United States
-
Texas Oncology- Gulf Coast
RECRUITINGThe Woodlands, Texas, 77380, United States
-
University of Chicago
RECRUITINGChicago, Illinois, 60637, United States
-
University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
-
University of Texas MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
-
Valkyrie Clinical Trials
RECRUITINGLos Angeles, California, 90067, United States
-
Virginica Cancer Specialists
RECRUITINGFairfax, Virginia, 22031, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a new drug shield nerves from Chemotherapy's side effects?
- Can a Tumor's DNA guide better cancer care for kids?
- A lifeline for cancer caregivers: can simple phone support reduce their stress?
- Can a new PET tracer reveal a key cancer target?
- Can a smart drug home in on Hard-to-Treat cancers?
- Tissue analysis may guide personalized cancer therapy