New drug combo aims to boost chemo for tough bone cancer

NCT ID NCT07477457

Recruiting now Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding four drugs (gefitinib, trametinib, disulfiram, and sunitinib) to standard chemotherapy helps people with osteosarcoma that has spread. About 45 participants with newly diagnosed or advanced disease will be enrolled. Researchers will check if the combination improves survival and how safe it is.

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Conditions

The condition(s) this trial relates to.

localized osteosarcoma metastatic neoplasm Neoplasm Metastasis osteosarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTASIS OSTEOSARCOMA

Contacts and locations

Locations

Memorial Sloan Kettering Cancer Center (All Protocol Activites)
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities)
RECRUITING

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering at Bergen (Limited Protocol Activities)
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering at Monmouth (Limited Protocol Activities)
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering at Nassau (Limited Protocol Activities)
RECRUITING

Uniondale, New York, 11553, United States
Memorial Sloan Kettering at Suffolk-Commack (Limited Protocol Activities)
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering at Westchester (Limited Protocol Activities)
RECRUITING

Harrison, New York, 10604, United States

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