METASTASIS

This study is testing whether adding four targeted drugs (gefitinib, trametinib, disulfiram, and sunitinib) to standard chemotherapy works better than standard chemo alone for people with metastatic osteosarcoma, a serious bone cancer. It will enroll about 45 participants, includ…

This study is testing a new oral medication called Alintegimod, given alongside the immunotherapy drugs ipilimumab and nivolumab. It aims to see if this combination is safe and can help control advanced cancers that have spread or returned after other treatments. The study will e…

This study is testing a new drug called ifinatamab deruxtecan, both by itself and combined with other treatments, for men with advanced prostate cancer that has spread and no longer responds to standard hormone therapy. The main goals are to find a safe dose, see how well the bod…

This early-stage study is testing a new way to deliver radiation for hard-to-treat lung tumors located near the heart or major airways. It aims to see if giving fewer, more powerful radiation doses spaced weeks apart, guided by real-time MRI scans, can be safer for patients while…

This early-stage study is testing the safety of combining two drugs, atezolizumab and ONC201, for women with advanced or returning endometrial cancer that has spread. The trial will enroll 58 participants, including both obese and non-obese patients, to find the best dose for fut…

This early-stage study is testing the safety of a new experimental injection called Peptide Alarm Therapy (PAT) when given directly into tumors alongside standard immunotherapy. It's for adults with advanced solid tumors that have continued to grow despite one or more prior treat…

This study is testing whether adding a new drug called azeliragon to a precise form of radiation therapy is safe and more effective at controlling brain tumors that have spread from other cancers. It will involve about 46 adult patients with small brain tumors. The main goal is t…

This study is testing a new imaging technique to help surgeons see if breast cancer has spread to nearby lymph nodes during surgery. Doctors apply a special fluorescent dye to the removed lymph node tissue and use a special camera to see if cancer cells are present. The goal is t…

This study aims to find out if removing the main tumor helps patients with advanced small intestinal neuroendocrine tumors that have spread and cannot be cured. It will compare the long-term survival and complication rates of patients who had surgery to those who received medicat…

This study aims to understand how the amount of radiation delivered by a prostate cancer treatment affects patient outcomes and side effects. Researchers will observe 50 patients with advanced prostate cancer who are receiving a standard treatment called 177Lu-PSMA-617. They will…

This study looks back at the medical records of about 350 people whose cervical cancer returned or spread to a few new sites. Researchers want to understand which combinations of treatments—like chemotherapy, radiation, or surgery—led to the best survival and quality of life. The…