METASTASIS

This study tests an experimental oral drug called Alintegimod combined with standard immunotherapies (ipilimumab and nivolumab) in people with advanced solid tumors like melanoma, lung, kidney, or liver cancer who have already tried other treatments. The goal is to see if the com…

This early-phase study tests a new approach called peptide alarm therapy (PAT) given as an injection directly into tumors, along with a standard immunotherapy drug, for people with advanced solid tumors that have stopped responding to at least one prior treatment. The goal is to …

This study tests a new way to give radiation therapy for lung tumors located near the center of the chest, which are hard to treat safely. The approach, called PULSAR, uses very precise, high-dose radiation given in multiple sessions over time. Researchers want to see if this met…

This study tests whether adding the drug azeliragon to targeted radiation therapy can safely shrink brain tumors and keep them under control longer. About 46 adults with cancer that has spread to the brain will receive the combination. The goal is to improve tumor response and de…

This study tests whether adding four drugs (gefitinib, trametinib, disulfiram, and sunitinib) to standard chemotherapy helps people with osteosarcoma that has spread live longer. About 45 participants with newly diagnosed or advanced disease will be enrolled. Researchers will als…

This study tests a new drug called ifinatamab deruxtecan, given alone or with other treatments, in people whose prostate cancer has spread and stopped responding to hormone therapy. The goal is to find safe doses and see if the drug can shrink tumors or lower PSA levels. About 36…

This study tests a combination of two drugs, abemaciclib and bicalutamide, for people with a specific type of advanced breast cancer that has spread (metastatic). The cancer must test positive for androgen receptors and negative for HER2. The goal is to find the best dose and see…

This early-stage study tests the safety of combining two drugs, atezolizumab and ONC201, for women with advanced or recurrent endometrial cancer. The trial includes both obese and non-obese participants to see how body weight affects treatment. Researchers aim to find the best do…

This study tests a special dye that makes cancer cells glow, helping surgeons quickly tell if a lymph node contains cancer during breast cancer surgery. About 60 adults with breast cancer will have their removed lymph nodes treated with the dye and then imaged. The goal is to see…

This study looks at people with a rare type of small intestinal cancer that has spread and cannot be fully cured. It compares those who had surgery to remove the main tumor with those who did not, to see who lives longer and has fewer complications. The goal is to give doctors cl…

This study looks at a radioactive treatment called 177Lu-PSMA-617 for men with advanced prostate cancer that has spread. Researchers want to measure how much radiation the tumor and healthy organs receive, and see if that affects how well the treatment works or causes side effect…

This study looks back at medical records of 350 people with cervical cancer that has come back or spread to only a few places. The goal is to see how well different treatments like radiation, surgery, or chemotherapy work. By understanding what helps these patients live longer, d…