New drug combo takes on Hard-to-Treat prostate cancer

NCT ID NCT06863272

Recruiting now Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 31, 2026 · Updated 4 times

Summary

This study tests a new drug called ifinatamab deruxtecan (I-DXd), given alone or with other treatments, in men with metastatic castration-resistant prostate cancer (mCRPC) that has worsened despite hormone therapy. The trial aims to find safe doses and see if the drug can lower PSA levels and shrink tumors. About 360 participants will take part across multiple sites.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ifinatamab deruxtecan (I-DXd), docetaxel, MK-5684, abiraterone, enzalutamide
What this could lead to: If it works, this could point toward a new treatment option for men with advanced prostate cancer that has stopped responding to hormone therapy.
What could go wrong: This is an early-phase trial (Phase 1/2) with a small number of participants, so the drug may not prove effective or safe enough for wider use. Side effects could be serious, including severe toxicities.

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Conditions

The condition(s) this trial relates to.

castration-resistant prostate carcinoma metastatic neoplasm metastatic prostate carcinoma Neoplasm Metastasis Prostatic Neoplasms, Castration-Resistant

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CASTRATION RESISTANT PROSTATIC CANCER METASTASIS

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

A.O.U. Federico II di Napoli ( Site 0435)
RECRUITING

Naples, 80131, Italy
AOU San Luigi Gonzaga di Orbassano ( Site 0434)
RECRUITING

Orbassano, Torino, 10143, Italy
Addenbrooke's Hospital ( Site 0747)
RECRUITING

Cambridge, Cambridgeshire, CB2 2QQ, United Kingdom
Ankara Bilkent Şehir Hastanesi ( Site 0654)
RECRUITING

Ankara, 06800, Turkey (Türkiye)
Ankara Universitesi Tip Fakultesi Hastanesi ( Site 0653)
RECRUITING

Ankara, 06620, Turkey (Türkiye)
Asan Medical Center ( Site 0925)
RECRUITING

Songpagu, Seoul, 05505, South Korea
Auckland City Hospital ( Site 0831)
RECRUITING

Auckland, 1023, New Zealand
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia ( Site 0432)
RECRUITING

Brescia, 25123, Italy
BC Cancer - Vancouver Center ( Site 0103)
RECRUITING

Vancouver, British Columbia, V5Z 4E6, Canada
Baskent University Dr. Turgut Noyan Research and Training Center ( Site 0650)
RECRUITING

Adana, 01250, Turkey (Türkiye)
Beaumont Hospital, Dublin ( Site 0465)
RECRUITING

Dublin, D09 V2N0, Ireland
Bradfordhill ( Site 0231)
RECRUITING

Santiago, Region M. de Santiago, 8420383, Chile
CIUSSS de l Estrie - CHUS - Centre Hosp. Univ. Sherbrooke ( Site 0107)
RECRUITING

Sherbrooke, Quebec, J1H 5N4, Canada
Centre Hospitalier de la Cote Basque ( Site 0496)
RECRUITING

Bayonne, Pyrenees-Atlantiques, 64100, France
Centre Oscar Lambret ( Site 0495)
RECRUITING

Lille, Nord, 59000, France
Centro de Oncología de Precisión ( Site 0241)
RECRUITING

Santiago, Region M. de Santiago, 7560908, Chile
Clinica Universidad Catolica del Maule ( Site 0236)
RECRUITING

Talca, Maule Region, 3465584, Chile
FALP ( Site 0232)
RECRUITING

Santiago, Region M. de Santiago, 7500921, Chile
Fondazione IRCCS Istituto Nazionale Dei Tumori ( Site 0431)
RECRUITING

Milan, 20133, Italy
Fondazione Policlinico Universitario Agostino Gemelli ( Site 0433)
RECRUITING

Roma, 00168, Italy
Fred Hutchinson Cancer Center ( Site 0013)
RECRUITING

Seattle, Washington, 98109, United States
Fundación CORI para la Investigación y Prevención del Cáncer ( Site 0200)
RECRUITING

La Rioja, F5300COE, Argentina
Fundação Faculdade Regional de Medicina de São José do Rio Preto ( Site 0263)
RECRUITING

São José do Rio Preto, São Paulo, 15090-000, Brazil
Hacettepe Universitesi Tip Fakultesi ( Site 0648)
RECRUITING

Ankara, 06230, Turkey (Türkiye)
Hadassah Medical Center ( Site 0404)
RECRUITING

Jerusalem, 9112001, Israel
Hospital Alemao Oswaldo Cruz ( Site 0279)
RECRUITING

São Paulo, São Paulo, 01327-001, Brazil
Hospital Clinico San Carlos ( Site 0618)
RECRUITING

Madrid, 28040, Spain
Hospital Moinhos de Vento ( Site 0278)
RECRUITING

Porto Alegre, Rio Grande do Sul, 90035-001, Brazil
Hospital Universitario 12 de Octubre ( Site 0622)
RECRUITING

Madrid, 28041, Spain
Hospital Universitario Ramon y Cajal ( Site 0620)
RECRUITING

Madrid, 28034, Spain
Hospital Universitario Virgen del Rocio ( Site 0619)
RECRUITING

Seville, 41013, Spain
Hospital Universitário São Francisco de Assis - Bragança Paulista ( Site 0268)
RECRUITING

Bragança Paulista, São Paulo, 12916-542, Brazil
Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (USP) ( Site 0273)
RECRUITING

Ribeirão Preto, São Paulo, 14048900, Brazil
IBCC - Instituto Brasileiro de Controle do Câncer ( Site 0269)
RECRUITING

São Paulo, 03102-006, Brazil
ICO L Hospitalet ( Site 0617)
RECRUITING

L Hospitalet Del Llobregat, Barcelona, 08908, Spain
IPITEC ( Site 0275)
RECRUITING

São Paulo, 01221-020, Brazil
Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest ( Site 0498)
RECRUITING

Bordeaux, Gironde, 33000, France
Institut De Cancerologie De L Ouest ( Site 0494)
RECRUITING

Saint-Herblain, Pays de la Loire Region, 44800, France
Instituto Alexander Fleming ( Site 0202)
RECRUITING

Ciudad Autónoma de Buenos Aires, Buenos Aires, C1426ANZ, Argentina
Irmandade da Santa Casa de Misericórdia de Porto Alegre ( Site 0270)
RECRUITING

Porto Alegre, Rio Grande do Sul, 90020-090, Brazil
Istanbul Universitesi Cerrahpasa ( Site 0649)
RECRUITING

Istanbul, 34098, Turkey (Türkiye)
Koç Üniversitesi Hastanesi ( Site 0656)
RECRUITING

Istanbul, 34010, Turkey (Türkiye)
Liga Norte Riograndense Contra o Câncer ( Site 0271)
RECRUITING

Natal, Rio Grande do Norte, 59062-000, Brazil
Macquarie University-MQ Health Clinical Trials Unit ( Site 0801)
RECRUITING

Macquarie University, New South Wales, 2109, Australia
MedStar Georgetown Cancer Institute at MedStar Washington Hospital Center ( Site 0026)
RECRUITING

Washington D.C., District of Columbia, 20010, United States
Memorial Sloan Kettering Cancer Center ( Site 0006)
RECRUITING

New York, New York, 10065, United States
NCT ( Site 0528)
RECRUITING

Heidelberg, Baden-Wurttemberg, 69120, Germany
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie ( Site 0586)
RECRUITING

Warsaw, Masovian Voivodeship, 02-781, Poland
Nij Smellinghe ( Site 0684)
RECRUITING

Drachten, Provincie Friesland, 9202 NN, Netherlands
ONCOCENTRO APYS ( Site 0234)
RECRUITING

Viña del Mar, Valparaiso, 2520598, Chile
Princess Margaret Cancer Centre ( Site 0102)
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
Rabin Medical Center ( Site 0402)
RECRUITING

Petah Tikva, 4941492, Israel
Rambam Health Care Campus ( Site 0400)
RECRUITING

Haifa, 3109601, Israel
Recep Tayyip Erdogan University Training and Research Hospital ( Site 0655)
RECRUITING

Rize, 53020, Turkey (Türkiye)
Royal Free Hospital ( Site 0743)
RECRUITING

London, London, City of, NW3 2QG, United Kingdom
Royal Marsden Hospital (Sutton) ( Site 0741)
RECRUITING

London, Surrey, SM3 5PT, United Kingdom
Samsung Medical Center ( Site 0926)
RECRUITING

Seoul, 06351, South Korea
Severance Hospital Yonsei University Health System ( Site 0924)
ACTIVE_NOT_RECRUITING

Seoul, 03722, South Korea
Sheba Medical Center ( Site 0401)
RECRUITING

Ramat Gan, 5265601, Israel
Sourasky Medical Center ( Site 0403)
RECRUITING

Tel Aviv, 6423906, Israel
St Bartholomew's Hospital ( Site 0749)
RECRUITING

London, London, City of, EC1A 7BE, United Kingdom
St Vincent's University Hospital ( Site 0463)
RECRUITING

Dublin, Dublin, D04 T6F4, Ireland
Sunnybrook Research Institute ( Site 0109)
RECRUITING

Toronto, Ontario, M4N 3M5, Canada
Szpital Wojewódzki im. M.Kopernika Oddział Onk. Klinicznej z Pododdziałem Chemioterapii Jednodniowej ( Site 0587)
RECRUITING

Koszalin, West Pomeranian Voivodeship, 75-581, Poland
Taichung Veterans General Hospital ( Site 0902)
RECRUITING

Taichung, 40705, Taiwan
Taipei Veterans General Hospital ( Site 0901)
RECRUITING

Taipei, 11217, Taiwan
Tallaght University Hospital ( Site 0462)
RECRUITING

Dublin, D24 NR0A, Ireland
The West Clinic, PLLC dba West Cancer Center ( Site 0005)
RECRUITING

Germantown, Tennessee, 38138, United States
UCLA Hematology & Oncology ( Site 0003)
RECRUITING

Los Angeles, California, 90095, United States
UCSF Medical Center at Mission Bay ( Site 0034)
RECRUITING

San Francisco, California, 94158, United States
UMC St. Radboud ( Site 0679)
RECRUITING

Nijmegen, Gelderland, 6525 GA, Netherlands
UPMC Hillman Cancer Center ( Site 0014)
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
Universitaetsklinikum Hamburg-Eppendorf ( Site 0524)
RECRUITING

Hamburg, 20246, Germany
Universitaetsklinikum Jena ( Site 0525)
RECRUITING

Jena, Thuringia, 07747, Germany
Universitaetsklinikum Ulm. ( Site 0530)
RECRUITING

Ulm, Baden-Wurttemberg, 89081, Germany
University of California-Irvine Medical Center ( Site 0016)
RECRUITING

Orange, California, 92868, United States
University of Michigan ( Site 0021)
RECRUITING

Ann Arbor, Michigan, 48109, United States
Uniwersytecki Szpital Kliniczny w Poznaniu ( Site 0590)
RECRUITING

Poznan, Greater Poland Voivodeship, 60-355, Poland
Uniwersyteckie Centrum Kliniczne ( Site 0588)
RECRUITING

Gdansk, Pomeranian Voivodeship, 80-214, Poland
Ziekenhuis Gelderse Vallei ( Site 0683)
RECRUITING

Ede, Gelderland, 6716 RP, Netherlands
centre hospitalier lyon sud ( Site 0497)
RECRUITING

Pierre-Bénite, Rhone, 69310, France

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