Immune cells supercharged to fight advanced cancers

NCT ID NCT06060613

Recruiting now Disease control Sponsor: Obsidian Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 4 times

Summary

This study tests an experimental treatment called OBX-115 for people with advanced melanoma or non-small cell lung cancer that has spread or stopped responding to standard therapy. OBX-115 uses a patient's own immune cells (tumor-infiltrating lymphocytes) that are modified in the lab to include a protein (IL15) that helps them survive and attack tumors. The goal is to see if this approach can shrink tumors safely. About 208 adults will take part in this early-phase trial.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for LUNG CANCER are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

lung cancer lung neoplasm melanoma metastatic malignant neoplasm metastatic melanoma non-small cell lung carcinoma skin neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUNG CANCER MELANOMA METASTATIC LUNG CANCER METASTATIC MELANOMA METASTATIC NON-SMALL CELL LUNG CANCER NON-SMALL CELL LUNG CANCER TUMOR SKIN

Contacts and locations

Locations

Allegheny Research Institute (Melanoma/NSCLC)
RECRUITING

Pittsburgh, Pennsylvania, 15224, United States
James Graham Brown Cancer Center (Melanoma/NSCLC)
RECRUITING

Louisville, Kentucky, 40202, United States
M.D. Anderson Cancer Center (Melanoma/NSCLC)
RECRUITING

Houston, Texas, 77030, United States
Melanoma Institute of Australia
RECRUITING

Wollstonecraft, New South Wales, 2065, Australia
Memorial Sloan Kettering (Melanoma/NSCLC)
RECRUITING

New York, New York, 10065, United States
Orlando Health Cancer Institute (Melanoma/NSCLC)
RECRUITING

Orlando, Florida, 32806, United States
Stanford Cancer Institute (Melanoma/NSCLC)
RECRUITING

Stanford, California, 94305, United States
The Angeles Clinic and Research Institute (Melanoma)
RECRUITING

Los Angeles, California, 90025, United States
The Ohio State University
ACTIVE_NOT_RECRUITING

Columbus, Ohio, 43210, United States
USC Norris Comprehensive Cancer Center (Melanoma/NSCLC)
RECRUITING

Los Angeles, California, 90033, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.