Gene-Guided cancer therapy: a new hope for advanced tumors?

NCT ID NCT05525858

Recruiting now Knowledge-focused Sponsor: Seoul National University Bundang Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study enrolls 1,000 adults with advanced solid tumors that have progressed after standard treatment. Researchers will use genetic tests to match patients to specific drugs, like Alectinib or Atezolizumab, based on their tumor's gene changes. The goal is to see if this personalized approach is feasible and helps control the cancer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Alectinib, Atezolizumab, and other targeted/immunotherapies based on genomic alterations
What this could lead to: If successful, this could show that using genetic tests to choose cancer treatments improves outcomes for people with advanced solid tumors who have run out of standard options.
What could go wrong: This is an early-stage feasibility study, not a large confirmatory trial. The treatments are used outside their approved indications, so benefits are uncertain and there may be unexpected side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

metastatic malignant neoplasm neoplasm Neoplasm Metastasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMOR METASTATIC CANCER SOLID TUMOR

Contacts and locations

Locations

Ajou University Hospital
RECRUITING

Suwon, South Korea
Asan Medical Center
RECRUITING

Seoul, South Korea
Cha University Bundang Medical Center
RECRUITING

Seongnam, South Korea
Chonnam National University Hwasun Hospital
RECRUITING

Hwasun, South Korea
Chung-ang University Hospital
RECRUITING

Seoul, South Korea
Chungbuk National University Hospital
RECRUITING

Chungju, South Korea
Chungnam National University Hospital
RECRUITING

Daejeon, South Korea
Dong-A University Hospital
RECRUITING

Pusan, South Korea
Ewha womans university Mokdong Hospital
RECRUITING

Seoul, South Korea
Gachon University Gil Medical Center
RECRUITING

Incheon, South Korea
Gangbuk Samsung Hospital
RECRUITING

Seoul, South Korea
Gyeongsang National University Hospital
RECRUITING

Jinju, South Korea
Hanyang University Hospital
TERMINATED

Seoul, South Korea
Jeonbuk National University Hospital
RECRUITING

Jeonju, South Korea
Keimyung University Dongsan Hospital
RECRUITING

Daegu, South Korea
Korea University Anam Hospital
RECRUITING

Seoul, South Korea
Korea University Guro Hospital
RECRUITING

Seoul, South Korea
Kyungpook National University Chilgok Hospital
RECRUITING

Daegu, South Korea
National Cancer Center
RECRUITING

Goyang, South Korea
Pusan National University Yangsan Hospital
RECRUITING

Yangsan, South Korea
Samsung Medical Center
RECRUITING

Seoul, South Korea
Seoul National University Bundang Hospital
RECRUITING

Seongnam, South Korea
Seoul National University Hospital
RECRUITING

Seoul, South Korea
Soonchunhyang University Hospital Bucheon
RECRUITING

Bucheon-si, South Korea
The Catholic University of Korea, Incheon St. Mary's Hospital
RECRUITING

Incheon, South Korea
The Catholic University of Korea, ST. Vincent's Hospital
RECRUITING

Suwon, South Korea
The Catholic University of Korea, Seoul ST. Mary's Hospital
RECRUITING

Seoul, South Korea
The Catholic University of Korea, Yeouido St. Mary's Hospital
RECRUITING

Seoul, South Korea
Ulsan University Hospital
RECRUITING

Ulsan, South Korea
Wonju Severance Christian Hospital
TERMINATED

Wŏnju, South Korea
Yeungnam University Medical Center
RECRUITING

Daegu, South Korea
Yonsei Cancer Hospital
RECRUITING

Seoul, South Korea

More trials for these conditions

Other studies related to the condition(s) this trial covers.