New pill targets hard-to-treat cancers with specific gene flaw

NCT ID NCT07284186

Recruiting now Disease control Sponsor: Plexium, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new experimental drug called PLX-61639 for people with advanced solid tumors that have a specific genetic change (SMARCA4 mutation) and have stopped responding to standard treatments. The drug is taken as a daily pill and aims to shrink or control the cancer. About 155 adults will take part to see if the drug is safe and how well it works.

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Conditions

The condition(s) this trial relates to.

adenocarcinoma Adenocarcinoma Of Esophagus esophageal adenocarcinoma esophageal squamous cell carcinoma gastric adenocarcinoma gastric squamous cell carcinoma gastroesophageal junction adenocarcinoma metastatic malignant neoplasm Neoplasm Metastasis non-small cell lung carcinoma SMARCA4-deficient sarcoma of thorax

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMOR ESOPHAGEAL ADENOCARCINOMA ESOPHAGEAL SQUAMOUS CELL CARCINOMA GASTRIC ADENOCARCINOMA GASTRIC SQUAMOUS CELL CARCINOMA GASTROESOPHAGEAL JUNCTION (GEJ) ADENOCARCINOMA GASTROESOPHAGEAL JUNCTION SQUAMOUS CELL CARCINOMA METASTATIC SOLID TUMOR NON-SMALL CELL LUNG CARCINOMA SMARCA4 MUTATION

Contacts and locations

Locations

Research Site
RECRUITING

Scottsdale, Arizona, 85258, United States
Research Site
RECRUITING

Duarte, California, 91010, United States
Research Site
RECRUITING

Orange, California, 92868, United States
Research Site
RECRUITING

Boston, Massachusetts, 02114, United States
Research Site
RECRUITING

St Louis, Missouri, 63110, United States
Research Site
RECRUITING

New York, New York, 10044, United States
Research Site
RECRUITING

Durham, North Carolina, 27710, United States
Research Site
RECRUITING

Cleveland, Ohio, 44106, United States
Research Site
RECRUITING

San Antonio, Texas, 78229, United States
Research Site
RECRUITING

Fairfax, Virginia, 22031, United States

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