Old antibiotic, new hope: novobiocin targets Cancer's weak DNA repair
NCT ID NCT05687110
First seen Jun 26, 2026 · Last updated Aug 04, 2026 · Updated 5 times
Summary
This early-phase trial tests an antibiotic called novobiocin in people with advanced solid tumors that have specific DNA repair mutations (like BRCA). The drug blocks a protein cancer cells use to fix their damaged DNA, which may cause them to die. The study aims to find the safest dose and see if it can shrink or stabilize tumors.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Novobiocin (an antibiotic that blocks a DNA repair protein)
- What this could lead to
- If it works, this could point toward a new treatment option for people with certain DNA repair-deficient cancers that have stopped responding to standard therapies.
- What could go wrong
- This is a very early, small Phase 1 trial focused on safety and dosing, not yet on effectiveness. The drug may not shrink tumors or may cause side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Beth Israel Deaconess Medical Center
RECRUITINGBoston, Massachusetts, 02215, United States
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City of Hope Comprehensive Cancer Center
RECRUITINGDuarte, California, 91010, United States
Contact Email: •••••@•••••
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Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02215, United States
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Fred Hutchinson Cancer Center
RECRUITINGSeattle, Washington, 98109, United States
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Huntsman Cancer Institute/University of Utah
RECRUITINGSalt Lake City, Utah, 84112, United States
Contact Email: •••••@•••••
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Laura and Isaac Perlmutter Cancer Center at NYU Langone
RECRUITINGNew York, New York, 10016, United States
Contact Email: •••••@•••••
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Los Angeles General Medical Center
RECRUITINGLos Angeles, California, 90033, United States
Contact Email: •••••@•••••
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NYU Langone Hospital - Long Island
RECRUITINGMineola, New York, 11501, United States
Contact Email: •••••@•••••
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National Cancer Institute Developmental Therapeutics Clinic
RECRUITINGBethesda, Maryland, 20892, United States
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National Institutes of Health Clinical Center
ACTIVE_NOT_RECRUITINGBethesda, Maryland, 20892, United States
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Ohio State University Comprehensive Cancer Center
RECRUITINGColumbus, Ohio, 43210, United States
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UC Irvine Health/Chao Family Comprehensive Cancer Center
ACTIVE_NOT_RECRUITINGOrange, California, 92868, United States
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UC San Diego Medical Center - Hillcrest
RECRUITINGSan Diego, California, 92103, United States
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UC San Diego Moores Cancer Center
RECRUITINGLa Jolla, California, 92093, United States
Contact Email: •••••@•••••
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UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
ACTIVE_NOT_RECRUITINGIrvine, California, 92612, United States
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USC / Norris Comprehensive Cancer Center
RECRUITINGLos Angeles, California, 90033, United States
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University Health Network-Princess Margaret Hospital
ACTIVE_NOT_RECRUITINGToronto, Ontario, M5G 2M9, Canada
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University of California Davis Comprehensive Cancer Center
ACTIVE_NOT_RECRUITINGSacramento, California, 95817, United States
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University of Chicago Comprehensive Cancer Center
RECRUITINGChicago, Illinois, 60637, United States
Contact Email: •••••@•••••
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University of Oklahoma Health Sciences Center
RECRUITINGOklahoma City, Oklahoma, 73104, United States
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University of Washington Medical Center - Montlake
RECRUITINGSeattle, Washington, 98195, United States
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University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
RECRUITINGMadison, Wisconsin, 53718, United States
Contact Email: •••••@•••••
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University of Wisconsin Carbone Cancer Center - University Hospital
RECRUITINGMadison, Wisconsin, 53792, United States
Contact Email: •••••@•••••
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Other studies related to the condition(s) this trial covers.
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