One shot or two? trial tests best radiation recipe for spine cancer

NCT ID NCT06173401

Recruiting now Disease control Sponsor: Stanford University Source: ClinicalTrials.gov ↗

First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time

Summary

This trial is testing whether giving radiation in two separate doses works better than a single high dose for people with cancer that has spread to the spine. The goal is to see which approach controls tumor growth longer while keeping side effects low. About 274 adults with up to three spinal tumors will be randomly assigned to one of the two radiation schedules.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: radiation therapy (stereotactic radiosurgery) given as either a single high dose or two lower doses
What this could lead to: If multi-fraction radiosurgery proves better, it could become the new standard for treating spinal metastases, offering longer tumor control with fewer side effects.
What could go wrong: This is an early-phase comparison; multi-fraction treatment may not improve outcomes and could be less convenient. Radiation risks include pain flare, fracture, or nerve damage.

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Conditions

The condition(s) this trial relates to.

metastatic malignant neoplasm in the spinal cord Neoplasm Metastasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SPINAL METASTASES

Contacts and locations

Locations

Stanford University School of Medicine
RECRUITING

Palo Alto, California, 94305, United States

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