New imaging technique could reveal how radiation wakes up the immune system

NCT ID NCT05371132

Recruiting now Knowledge-focused Sponsor: City of Hope Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial is testing whether a special PET scan can track immune cells called CD8+ T cells in cancer patients before and after radiation therapy. The study includes 10 people with lymphoma or solid tumors that have spread. Researchers hope this imaging method could offer a less invasive way to see how radiation affects the immune system, which may help improve future treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Zirconium Zr 89-Df-Crefmirlimab (a radioactive tracer for PET scans)
What this could lead to: If successful, this could provide a less invasive way to monitor immune activity in tumors after radiation, potentially guiding future combination therapies.
What could go wrong: This is a very small, early-phase pilot study with only 10 participants, so results may not apply broadly. The imaging technique may not reliably reflect immune response.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

lymphoma metastatic malignant neoplasm Neoplasm Metastasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LYMPHOMA METASTATIC MALIGNANT SOLID NEOPLASM

Contacts and locations

Locations

City of Hope Medical Center
RECRUITING

Duarte, California, 91010, United States

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