New imaging technique could reveal how radiation wakes up the immune system
NCT ID NCT05371132
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase trial is testing whether a special PET scan can track immune cells called CD8+ T cells in cancer patients before and after radiation therapy. The study includes 10 people with lymphoma or solid tumors that have spread. Researchers hope this imaging method could offer a less invasive way to see how radiation affects the immune system, which may help improve future treatments.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Zirconium Zr 89-Df-Crefmirlimab (a radioactive tracer for PET scans)
What this could lead to
If successful, this could provide a less invasive way to monitor immune activity in tumors after radiation, potentially guiding future combination therapies.
What could go wrong
This is a very small, early-phase pilot study with only 10 participants, so results may not apply broadly. The imaging technique may not reliably reflect immune response.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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City of Hope Medical Center
RECRUITINGDuarte, California, 91010, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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