New drug targets 13 cancers in major trial

NCT ID NCT06330064

Recruiting now Disease control Sponsor: Daiichi Sankyo Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 06, 2026 · Updated 2 times

Summary

This study tests a drug called ifinatamab deruxtecan (I-DXd) in people with 13 types of advanced solid tumors that have come back or spread. The trial aims to see how well the drug shrinks tumors and what side effects it causes. About 520 participants will receive the drug intravenously, and the study is currently recruiting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ifinatamab deruxtecan (I-DXd)
What this could lead to: If successful, this could provide a new treatment option for several advanced cancers that have stopped responding to standard therapies.
What could go wrong: This is an early-phase trial (Phase 1B/2) with no control group, so results may not confirm benefit. Side effects from the drug could be significant, and not all tumor types may respond.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Adenocarcinoma Of Esophagus Biliary Tract Neoplasms colorectal neoplasm endometrium neoplasm hepatocellular carcinoma melanoma metastatic malignant neoplasm neuroendocrine carcinoma ovarian cancer Recurrence Squamous Cell Carcinoma of Head and Neck transitional cell carcinoma Uterine Cervical Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RECURRENT OR METASTATIC SOLID TUMORS

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Aichi Cancer Center Hospital
RECRUITING

Nagoya, Aichi-ken, 464-8681, Japan
Aidport Sp Z O.O.
RECRUITING

Skorzewo, 60-185, Poland
Amsterdam Umc, Locatie Vumc
RECRUITING

Amsterdam, 1081 HV, Netherlands
Ankara City Hospital
RECRUITING

Ankara, 06800, Turkey (Türkiye)
Ankara University Cebeci Hospital
NOT_YET_RECRUITING

Ankara, 6590, Turkey (Türkiye)
Azienda Socio Sanitaria Territoriale Niguarda (Grande Ospedale Metropolitano Niguarda)
RECRUITING

Milan, 20162, Italy
Biocenter
RECRUITING

Concepción, Biobio, 4030000, Chile
Blacktown Hospital
RECRUITING

Blacktown, New South Wales, NSW 2148, Australia
CRLCC Eugene Marquis
RECRUITING

Rennes, Ille Et Vilaine, 35042, France
Centre Georges François Leclerc
RECRUITING

Dijon, Cote dÝOr, 21000, France
Centre Léon Bérard
RECRUITING

Lyon, Rhone, 69008, France
Centro Del Cancer UC
RECRUITING

Santiago, Santiago Metropolitan, 8320000, Chile
Centro Hospitalar Universitario de Santo Antonio
RECRUITING

Porto, 4099-001, Portugal
Centro Hospitalar Universitário de Lisboa Norte
RECRUITING

Lisbon, 1649-035, Portugal
Centro Médico Austral
ACTIVE_NOT_RECRUITING

Ciudad Autonoma Buenos Aires, 1019, Argentina
Centro de Atenciăn E Investigaciăn Clănica En Oncologăa
ACTIVE_NOT_RECRUITING

Mérida, 97134, Mexico
Centro de Investigaciones Medicas Mar Del Plata
RECRUITING

Mar del Plata, Buenos Aires, B7600FYK, Argentina
Centro de Investigaciones Medicas y Desarrollo LC SRL LC Investigacion
RECRUITING

Ciudad Autonoma Buenos Aires, C1113AAE, Argentina
Centro de Pesquisas Clinicas da Fundação Doutor Amaral Carvalho
RECRUITING

Jaú, São Paulo, 17210-120, Brazil
Cepon - Centro de Pesquisas Oncolăgicas de Santa Catarina
RECRUITING

Florianópolis, Santa Catarina, 88034-000, Brazil
Charită - Campus Charită Mitte
RECRUITING

Berlin, 13353, Germany
China Medical University Hospital
RECRUITING

Taichung, 404327, Taiwan
Chu Besançon - Hôpital Jean Minjoz
ACTIVE_NOT_RECRUITING

Besançon, 25000, France
Chu de Liăge
NOT_YET_RECRUITING

Liège, 4000, Belgium
Clinica Redsalud Vitacura
RECRUITING

Santiago, Santiago Metropolitan, 8320000, Chile
Clinical Research Alliance, Inc
RECRUITING

Westbury, New York, 11590, United States
Cliniques Universitaires Saint-Luc
RECRUITING

Brussels, 1200, Belgium
Cork University Hospital
NOT_YET_RECRUITING

Cork, T12DC4A, Ireland
Cryptex Investigacion Clinica S.A. de C.V.
ACTIVE_NOT_RECRUITING

México, 06100, Mexico
DIABAID
NOT_YET_RECRUITING

Buenos Aires, C1061ABD, Argentina
Erasmus Medisch Centrum
RECRUITING

Rotterdam, 3015 GD, Netherlands
Erlanger Health, Inc
RECRUITING

Chattanooga, Tennessee, 37403, United States
Fondazione Del Piemonte Per L'Oncologia Irccs Candiolo
RECRUITING

Candiolo, 10060, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori
RECRUITING

Milan, 20133, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
RECRUITING

Rome, 00168, Italy
Fundação Champalimaud
RECRUITING

Lisbon, 1400-038, Portugal
Gazi University Medical Faculty
RECRUITING

Ankara, 06560, Turkey (Türkiye)
Genesiscare North Shore Oncology
RECRUITING

St Leonards, New South Wales, 2065, Australia
Grand Hospital de Charleroi
RECRUITING

Charleroi, 6000, Belgium
Gulhane Training and Research Hospital
RECRUITING

Ankara, 06010, Turkey (Türkiye)
GustaveRoussy DptPharmacie
RECRUITING

Villejuif, Val De Marne, 94805, France
Hopital Saint Andre
RECRUITING

Bordeaux, Gironde, 33075, France
Hospital Aleman
RECRUITING

Buenos Aires, Ciudad Autonoma Buenos Aires, C1118AAT, Argentina
Hospital Clinic de Barcelona
RECRUITING

Barcelona, 08036, Spain
Hospital Clínico San Carlos
RECRUITING

Madrid, 28040, Spain
Hospital General Universitario Gregorio Marañon
RECRUITING

Madrid, 28009, Spain
Hospital Sirio Libanes
RECRUITING

Caba, Ciudad Autonoma Buenos Aires, C1419GEP, Argentina
Hospital São Lucas Da Pucrs
RECRUITING

Porto Alegre, Rio Grande do Sul, 90610-000, Brazil
Hospital Universitari Vall D'Hebron
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hospital Universitario La Paz
RECRUITING

Madrid, 28046, Spain
Hospital Universitario Virgen Macarena
RECRUITING

Seville, 41009, Spain
Hospital de Clínicas de Porto Alegre
RECRUITING

Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
Hospital de Câncer de Barretos - Fundação Pio XII
RECRUITING

Barretos, São Paulo, 14784-400, Brazil
Huntsman Cancer Institute, University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States
ICO l'Hospitalet - Hospital Duran i Reynals
RECRUITING

Barcelona, 08908, Spain
Ic La Serena Research
NOT_YET_RECRUITING

La Serena, 1720430, Chile
Icahn School of Medicine At Mount Sinai Prime
RECRUITING

New York, New York, 10029, United States
Ico - Site René Gauducheau
RECRUITING

Saint-Herblain, Loire Atlantique, 44800, France
Inst Portude Onco do Porto
RECRUITING

Porto, 4200-072, Portugal
Institut Bergonié
RECRUITING

Bordeaux, Gironde, 33076, France
Institut Claudius Regaud
NOT_YET_RECRUITING

Toulouse, 31059, France
Institut Curie - Site de Paris
RECRUITING

Paris, Paris, 75005, France
Institut Régional Du Cancer de Montpellier
RECRUITING

Montpellier, Herault, 34298, France
Instituto Portuguăs de Oncologia de Lisboa Francisco Gentil, Epe
RECRUITING

Lisbon, 1099-023, Portugal
Instytut MSF Sp. z o.o.
RECRUITING

Lodz, 90-302, Poland
Istituto Clinico Humanitas
RECRUITING

Rozzano, 20089, Italy
Istituto Nazionale Tumori Fondazione G. Pascale
RECRUITING

Naples, 80131, Italy
Izmir Medicalpark Hospital
NOT_YET_RECRUITING

Izmir, 35530, Turkey (Türkiye)
James Lind Centro de Investigacion Del Cancer
NOT_YET_RECRUITING

Temuco, 4800827, Chile
Kindai University Hospital
RECRUITING

Ōsaka-sayama, Osaka, 589-8511, Japan
Koo Foundation Sun Yat-Sen cancer center
RECRUITING

Taipei, 11259, Taiwan
Los Angeles Cancer Network
RECRUITING

Los Angeles, California, 91204, United States
M Health Fairview University of Minnesota Medical Center
RECRUITING

Minneapolis, Minnesota, 55114, United States
MRUK-MED i Spółka z ograniczoną odpowiedzialnością
RECRUITING

Rzeszów, 35-021, Poland
Mater Misericordiae University Hospital
RECRUITING

Dublin, D07 R2WY, Ireland
Mazowiecki Szpital Wojewodzki W Siedlcach Sp Z O O
RECRUITING

Siedlce, 08-110, Poland
Medical Care & Research Sa de Cv
ACTIVE_NOT_RECRUITING

Mérida, 97070, Mexico
Medipol Mega University Hospital
RECRUITING

Bağcılar, Istanbul, 34214, Turkey (Türkiye)
NYU Langone Health
RECRUITING

New York, New York, 10016, United States
National Cancer Center Hospital
RECRUITING

Chuo-ku, Tokyo, 104-0045, Japan
National Cancer Center Hospital East
RECRUITING

Kashiwa, Chiba, 277-8577, Japan
National Cheng Kung University Hospitalx
RECRUITING

Tainan, 70403, Taiwan
National Hospital Organization Shikoku Cancer Center
RECRUITING

Matsuyama, Ehime, 791-0280, Japan
National Taiwan University Hospital
RECRUITING

Taipei, 10002, Taiwan
Orchard Healthcare Research Inc
RECRUITING

Skokie, Illinois, 60077, United States
Pih Health Hematology Medical Oncology
RECRUITING

Whittier, California, 90602, United States
Princess Alexandra Hospital
RECRUITING

Woolloongabba, Queensland, 4102, Australia
Radboudumc Nijmegen
RECRUITING

Nijmegen, 6525 GA, Netherlands
SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
SPZOZ Szpital Uniwer w Krakowie
RECRUITING

Krakow, 30-688, Poland
Saitama Cancer Center
RECRUITING

Saitama, 362-0806, Japan
Shizuoka Cancer Center
RECRUITING

Nagaizumi-cho, Shizuoka, 411-8777, Japan
Slk-Kliniken Heilbronn Gmbh
RECRUITING

Heilbronn, Baden-Wurttemberg, 74078, Germany
St John of God Subiaco Hospital
RECRUITING

Subiaco, Western Australia, 6008, Australia
St Vincent'S Hospital Sydney
RECRUITING

Mount Kuring-Gai, New South Wales, 2080, Australia
St Vincent'S University Hospital
RECRUITING

Dublin, Dublin, D04 T6F4, Ireland
Staedtisches Klinikum Dresden Standort Dresden-Friedrichstadt
RECRUITING

Dresden, Saxony, 01067, Germany
Taipei Veterans General Hospital
RECRUITING

Taipei, 11217, Taiwan
Tallaght University Hospital
RECRUITING

Dublin, D24 NR0A, Ireland
Texas Oncology - West Texas
RECRUITING

Amarillo, Texas, 79124, United States
Texas Oncology Gulf Coast
RECRUITING

Pearland, Texas, 77584, United States
Texas Oncology, P.A.
RECRUITING

Dallas, Texas, 75246, United States
The Cancer Institute Hospital of Jfcr
RECRUITING

Koto-ku, Tokyo, 135-8550, Japan
The West Clinic
RECRUITING

Germantown, Tennessee, 38138, United States
Tri-Service General Hospital
RECRUITING

Taipei, 11490, Taiwan
Umc Utrecht
RECRUITING

Utrecht, 3584 CW, Netherlands
Univ der Johannes GutenbergU
RECRUITING

Mainz, Rhineland-Palatinate, 55131, Germany
Universitaetsklinikum Heidelberg
RECRUITING

Heidelberg, Baden-Wurttemberg, 69120, Germany
Universitair Medisch Centrum Groningen
RECRUITING

Groningen, 9713 GZ, Netherlands
Universitair Ziekenhuis Gent
NOT_YET_RECRUITING

Ghent, 9000, Belgium
University Hospital Galway
NOT_YET_RECRUITING

Galway, H91YR71, Ireland
Universitäres Krebszentrum Leipzig UCCL, UKL AöR
RECRUITING

Leipzig, Saxony, 04103, Germany
Universitätsklinikum Münster, Medizinische Klinik A
RECRUITING

Münster, North Rhine-Westphalia, 48149, Germany
Uz Leuven
RECRUITING

Leuven, 3000, Belgium
Valkyrie Clinical Trials
ACTIVE_NOT_RECRUITING

Los Angeles, California, 90067, United States
Virginia Cancer Specialists
RECRUITING

Fairfax, Virginia, 22031, United States
Vivantes Klinikum Neukoelln
RECRUITING

Berlin, 12351, Germany
Wenatchee Valley Hospital and Clinics
RECRUITING

Wenatchee, Washington, 98801, United States
White Plains Hospital
RECRUITING

White Plains, New York, 10601, United States

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