New imaging agent could reveal which cancers respond to immunotherapy
NCT ID NCT05888532
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase I/II trial tests a radioactive tracer called 64Cu-GRIP B, which targets granzyme B—a substance released by immune cells. By using PET scans, researchers hope to see immune activity in tumors and predict whether immunotherapy will work. The study involves about 91 adults with advanced genitourinary cancers like prostate, kidney, or bladder cancer. The main goals are to check safety and see if the tracer can measure immune responses over time.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- 64Cu-GRIP B (a radioactive tracer that targets granzyme B, an immune cell marker)
- What this could lead to
- If successful, this imaging method could help doctors see which tumors are responding to immunotherapy early on, guiding treatment decisions.
- What could go wrong
- This is an early-phase trial focused on safety and imaging, not treatment. The tracer may not reliably predict responses, and results may not apply to all cancers.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ADVANCED SOLID TUMOR are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
University of California, San Francisco
RECRUITINGSan Francisco, California, 94143, United States
Contact Email: •••••@•••••
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a new tracer light up hidden prostate cancer?
- Chemo combo vs. radioactive drug: which tames aggressive prostate cancer?
- Can your own immune cells beat advanced cancer?
- Could deep breaths before surgery ward off Post-Op confusion?
- Can a new pill outsmart resistant prostate cancer?
- A second look: MRI screening may spot hidden prostate cancers