Brain mets trial: can shorter radiation be just as good?

NCT ID NCT05378633

Recruiting now Disease control Sponsor: University Hospital Heidelberg Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two radiation therapies for people with 4 to 15 brain metastases from cancer: stereotactic radiosurgery (SRS), which is done in 1-2 sessions, versus whole-brain radiotherapy (WBRT), which takes 10 sessions. The goal is to see if SRS offers similar survival with better quality of life and fewer side effects. About 190 participants will be followed for survival, cognitive function, and daily independence.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Radiation therapy (stereotactic radiosurgery or whole-brain radiotherapy)
What this could lead to: If SRS proves as effective as WBRT but with fewer side effects, it could become the preferred treatment for patients with multiple brain metastases, offering better quality of life.
What could go wrong: This is a phase 2 trial with 190 participants, so results are preliminary. SRS may not control brain metastases as well as WBRT, and individual outcomes vary.

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Conditions

The condition(s) this trial relates to.

brain cancer lung neoplasm metastatic malignant neoplasm in the brain Neoplasm Metastasis non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN METASTASES NSCLC

Contacts and locations

Locations

University Hospital of Heidelberg, Radiation Oncology
RECRUITING

Heidelberg, 69120, Germany

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