Could a 4-Week radiation course be as good as 5 weeks for prostate cancer?

NCT ID NCT07483658

Recruiting now Disease control Sponsor: CHU de Quebec-Universite Laval Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 02, 2026 · Updated 3 times

Summary

This study compares two radiotherapy schedules for men whose prostate cancer has returned after surgery. The standard treatment takes 5 weeks, while the shorter one takes 4 weeks. Researchers want to see if the shorter schedule causes no more side effects and controls the cancer just as well. About 434 men will take part, and the study will run for 12 years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Radiotherapy (external beam radiation)
What this could lead to: If successful, this could offer men with recurrent prostate cancer a shorter, more convenient radiotherapy schedule with similar safety and cancer control.
What could go wrong: This is a non-inferiority trial, so the shorter schedule may prove less effective or cause different side effects. Results will take years, and the study is not yet recruiting.

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Conditions

The condition(s) this trial relates to.

digestive system disorder metastatic malignant neoplasm metastatic neoplasm Neoplasm Recurrence, Local prostate adenocarcinoma prostate cancer prostate neoplasm radiation injury urinary system disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BIOCHEMICAL RECURRENCE OF MALIGNANT NEOPLASM OF PROSTATE NEOPLASM RECURRENCE, LOCAL PROSTATE CANCER PROSTATE CANCER (POST PROSTATECTOMY) PROSTATIC NEOPLASMS RECCURENT/METASTATIC SOLID TUMOR DISEASE

Contacts and locations

Locations

CHU de Québec-Université Laval
RECRUITING

Québec, Quebec, G1G 5X1, Canada
Gatineau Hospital
NOT_YET_RECRUITING

Gatineau, Quebec, Canada
Hôpital Général Juif
NOT_YET_RECRUITING

Montreal, Quebec, H3T 1E2, Canada
McGill University Health Centre
NOT_YET_RECRUITING

Montreal, Quebec, H4A 3J1, Canada

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