PROSTATIC NEOPLASMS

This study is testing a new, highly focused radiation treatment for men with early-stage prostate cancer that is confined to one spot in the prostate. The goal is to see if delivering a high dose of radiation directly to the tumor in just two sessions can effectively control the …

This study is testing a new, more precise method of delivering radiation therapy for prostate cancer. The goal is to see if this 'adaptive' approach, which adjusts treatment daily based on body changes, can safely reduce side effects like bowel and urinary problems. The research …

This study is testing a new drug called Pocenbrodib to see if it is safe and can help control advanced prostate cancer that has spread and is no longer responding to standard hormone treatments. Researchers will give Pocenbrodib alone or combined with other cancer drugs to about …

This early-stage study is testing a new combination of two experimental drugs for men with advanced prostate cancer that has spread and is no longer responding to standard hormone therapy. The main goals are to find a safe and effective dose of the two drugs used together and to …

This early-stage study is testing a new two-drug combination for men with advanced prostate cancer that has spread and stopped responding to standard hormone therapy. The main goals are to find a safe and tolerable dose of the drugs working together and to see how well the body h…

This large, late-stage study is testing whether a new drug called opevesostat works better than current standard hormone therapies for men with advanced prostate cancer that has spread and stopped responding to prior treatment. The main goal is to see if opevesostat can keep the …

This large, late-stage study is testing a new targeted drug called ifinatamab deruxtecan against standard chemotherapy for men with advanced prostate cancer that has spread and stopped responding to hormone therapy. The main goal is to see if the new drug helps patients live long…

This study is testing a new radioactive drug called lutetium (177Lu) rhPSMA-10.1 for men with advanced prostate cancer that has spread and is no longer responding to standard hormone therapies. The goal is to find a safe and effective dose that can shrink tumors by delivering rad…

This is the first human study of an experimental cancer drug called DM002 for people with advanced solid tumors including ovarian, prostate, endometrial, and colorectal cancers. The study has two parts: first finding the safest dose, then testing that dose to see how well it work…

This study is testing a new type of PET scan to see how accurately it can detect prostate cancer that has spread to nearby lymph nodes. It will involve about 383 men with high-risk prostate cancer who are scheduled for surgery to remove their prostate. Researchers will compare th…

This study is testing whether a new type of PET scan can find aggressive prostate cancer better than the standard MRI scan in men who are being monitored instead of immediately treated. About 120 men with low-risk prostate cancer on active surveillance will get both the new PET s…

This small pilot study is testing whether acupuncture is a practical and helpful way to reduce hot flashes in men receiving hormone therapy for prostate cancer. 24 men will be randomly assigned to start acupuncture right away or after a waiting period, while all receive standard …

This study aims to better understand why some prostate cancers return after radiation treatment. Researchers will use detailed MRI scans and biopsies to closely examine the prostate before and after radiation therapy. The goal is to improve the detection of cancer recurrence and …

This study aims to understand how common and severe leg swelling (lymphedema) is after surgery for cancers of the bladder, prostate, testicles, or penis that involves removing lymph nodes. Researchers will follow 400 patients for up to two years, using questionnaires and leg meas…

This study follows men who have chosen 'active surveillance' for their low-risk prostate cancer, meaning they are closely monitored instead of immediately treated. Researchers will track 3000 participants over time with regular blood tests and biopsies. The main goal is to discov…

This study aims to understand how well men with advanced prostate cancer stick to their prescribed medication, apalutamide, in real-world settings. It will follow 270 patients in France for one year, using questionnaires to track their adherence and identify factors that make it …

This study aims to understand why some prostate cancers stop responding to standard treatments by collecting blood samples from patients. Researchers will analyze the genetic material in the blood to look for differences that might explain why the disease becomes more aggressive …

This study aims to learn more about which men with specific inherited genetic changes are most likely to develop prostate cancer. Researchers will follow 500 men, aged 30-75, who have these genetic changes but do not have prostate cancer. Participants will have regular health che…

This study aims to understand how doctors use the drug darolutamide in real-world clinics to treat men with metastatic prostate cancer that has spread at diagnosis. Researchers will look back at the medical records of about 1,400 men to see who gets the drug, how they take it, an…