PROSTATIC NEOPLASMS

This early-stage study tested a new drug called CC-94676 in men with advanced prostate cancer that had spread and was no longer responding to standard hormone therapies. The main goal was to find a safe dose and understand how the drug behaves in the body. Researchers also looked…

This small, early-stage study aimed to check the safety and side effects of combining two drugs, abemaciclib and darolutamide, for men with advanced prostate cancer that had spread and stopped responding to standard hormone therapy. It involved 10 participants and looked at how w…

This study tested whether the drug niraparib could help control advanced prostate cancer that had stopped responding to standard hormone therapies and had spread. It specifically enrolled 289 men whose cancer had specific problems with DNA repair, a genetic weakness the drug is d…

This study tested whether men with advanced prostate cancer who take abiraterone and prednisone pills could safely stop their regular hormone injections. Researchers wanted to see if testosterone levels would stay low enough to control the cancer without the injections. The trial…

This study tested a combination treatment for men newly diagnosed with prostate cancer that had spread to a few other sites in the body. The goal was to see if adding an immunotherapy drug (pembrolizumab), with or without an immune-boosting injection (SD-101), to standard radiati…

This study tested whether adding a new drug called darolutamide to standard hormone therapy helps men whose prostate cancer has spread. It involved 669 men and compared the combination to hormone therapy alone. The main goal was to see if the new combination could delay the cance…

This early-stage study tested a new oral drug called MK-5684 (opevesostat) in 14 Chinese men with advanced prostate cancer that had spread and stopped responding to standard hormone treatments. The main goals were to check the drug's safety, see how well it was tolerated, and mea…

This study tested a new type of PET scan designed to find and pinpoint prostate cancer tumors more accurately. It involved 195 men with newly diagnosed, high-risk prostate cancer who were scheduled for surgery. Researchers compared the scan results directly to tissue samples from…

This study tested a new, faster way to check PSA levels, a marker for prostate health. Researchers compared a simple test strip that uses a few drops of blood to the standard, more complex lab test. They wanted to see if the quick test was as accurate for monitoring patients with…

This study tested if two new, advanced imaging scans could find prostate cancers that a standard MRI scan might miss in patients planning for a targeted therapy or surgery. The goal was to create a more accurate 'map' of the cancer to help guide treatment decisions. Researchers c…

This study tested a new type of PET scan, using a tracer called [18F]CTT1057, to see how well it could find and locate returning prostate cancer in men whose PSA levels were rising after initial surgery or radiation. About 190 men participated, each receiving the new scan and a s…

This study tested a new artificial intelligence (AI) tool designed to help pathologists spot prostate cancer that has spread to lymph nodes. Researchers compared the AI's analysis of digital slides from 225 patients' lymph nodes against standard pathology reports. The goal was to…

This small pilot study tested whether a structured exercise program using wearable fitness trackers could help Black and Hispanic/Latino men with prostate cancer manage treatment side effects and improve their quality of life. The program combined exercise guidance with behaviora…

This study tested whether a remote monitoring app could improve quality of life for people with advanced cancer. It involved 411 adults with metastatic breast, lung, colorectal, or prostate cancer. Researchers compared patients using the app to report symptoms from home against p…

This study was a registry that observed and collected information on nearly 1,000 Japanese men with advanced, high-risk prostate cancer that had already spread. The goal was to understand how patients fare in real-world settings, tracking their survival, cancer progression, and q…

This study compared the total 5-year healthcare costs and patient outcomes between two prostate cancer surgery methods: robotic-assisted surgery and traditional open surgery. Researchers followed 90 patients with localized prostate cancer to track expenses, recovery, side effects…

This study looked at how long men 65 and older with advanced prostate cancer that responds to hormone therapy stayed on newer hormone treatments. Researchers analyzed Medicare insurance claims data from over 3,000 men who were prescribed these medications by their regular doctors…

This study aimed to understand how prostate cancer affects men's quality of life three years after diagnosis, when they're expected to have returned to normal life. Researchers compared 900 men with prostate cancer to similar men without cancer, all living in the same region of F…

This study investigated whether low oxygen levels in prostate tumors make them harder to treat. Researchers measured oxygen in tumors of 186 men before they started radiation therapy. The goal was to see if low oxygen predicts whether cancer will spread or become resistant to hor…

This study looked at whether the special tilted position used during robotic prostate cancer surgery increases pressure in the breathing tube, leading to more sore throats and hoarseness after surgery. Researchers monitored 50 men having either robotic or traditional open prostat…