PROSTATIC NEOPLASMS

This early-phase study tested an experimental drug called CC-94676 in 131 men with a type of advanced prostate cancer that has stopped responding to standard hormone treatments. The main goals were to check the drug's safety, find the right dose, and see if it could lower PSA lev…

This early-phase study tested the safety of combining two drugs, abemaciclib and darolutamide, in 10 men with a type of advanced prostate cancer that had spread and stopped responding to standard hormone therapy. The main goal was to see if the combination was safe and tolerable.…

This early-phase study tested a new treatment called JNJ-75229414 for men with a type of advanced prostate cancer that no longer responds to hormone therapy. The treatment uses the patient's own immune cells, modified to target a protein on cancer cells. The main goals were to fi…

This early-stage study tested a new drug called opevesostat (MK-5684) in 7 Japanese men with a type of advanced prostate cancer that no longer responds to standard hormone therapy. The main goals were to check the drug's safety and how the body processes it. All participants had …

This study tested whether adding darolutamide to standard hormone therapy (ADT) helps men with prostate cancer that has spread to other parts of the body. 669 men participated, and the goal was to see if the combination delayed cancer growth or death. Results showed improvement i…

This study tested a drug called niraparib in 289 men with a hard-to-treat type of prostate cancer that has spread and has specific DNA repair issues. The goal was to see if the drug could shrink tumors or slow the cancer's growth. Participants had already tried other treatments l…

This study tested whether adding the immunotherapy drug pembrolizumab (Keytruda) to targeted radiation could help control prostate cancer that has spread to a few places in the body. Twenty-three men with newly diagnosed, hormone-sensitive prostate cancer took part. The goal was …

This early-stage study tested a new drug called MK-5684 in 14 Chinese men with a type of advanced prostate cancer that no longer responds to standard hormone therapy. The main goal was to check the drug's safety and how the body processes it, not to prove it works. Participants t…

This study looked at whether men with advanced prostate cancer could safely stop their regular hormone injections (like leuprolide) while continuing to take the pills abiraterone and prednisone. The goal was to see if testosterone levels would stay low enough to control the cance…

This study tested whether adding apalutamide to standard hormone therapy after prostate removal surgery could delay cancer recurrence in 108 men with high-risk, non-spreading prostate cancer. The treatment aims to keep prostate-specific antigen (PSA) levels low, a sign that the c…

This study tested a new imaging agent called [18F]CTT1057 for PET scans to find where prostate cancer has returned in men with rising PSA levels after initial treatment. About 190 men with biochemical recurrence took part. The goal was to see how accurately the scan locates cance…

This study tested a new, rapid PSA test that uses a small drop of blood to quickly screen for prostate cancer. Researchers compared its accuracy to the standard lab test in 94 patients with prostate issues. The goal was to see if the faster test could reliably detect high PSA lev…

This study tested an artificial intelligence (AI) model to see if it can accurately detect when prostate cancer has spread to nearby lymph nodes. Researchers compared the AI's results to those from standard pathology reports. The goal was to see if the AI could help doctors find …

This study tested whether advanced PET-MRI scans can find prostate cancers that standard MRI might miss. 62 men who were considering focal therapy or prostate removal took part. The goal was to see if the new imaging could better map the cancer and help guide treatment decisions.

This study tested a new PET imaging agent called [18F]CTT1057 to see how well it can find prostate cancer tumors. 195 men with high-risk prostate cancer who were scheduled for surgery received the PET scan, and the results were compared to tissue samples taken during surgery. The…

This study tested a remote monitoring system called CONTINUUM+ CONNECT in 411 adults with metastatic breast, lung, colorectal, or prostate cancer. Participants used the system at home, with or without nursing support, while others received standard care. The goal was to see if th…

This pilot study tested a program called PROWESS for Black and Hispanic men with prostate cancer who are on hormone therapy (ADT). The program used a Fitbit and coaching to help men exercise more, reduce treatment side effects, and improve quality of life. Fourteen men took part,…

This study looked at oxygen levels inside prostate tumors in 186 men with early-stage prostate cancer. Researchers used a special needle through the rectum to measure oxygen before starting radiation or hormone therapy. The goal was to see if low oxygen levels make treatment less…

This study looked at the quality of life of 900 men who were diagnosed with prostate cancer 3 years earlier, comparing them to men of the same age without cancer. The goal was to see if patients had returned to a "normal" life. Researchers used a standard questionnaire to measure…

This study looked at 50 men having prostate surgery to see if changes in breathing tube pressure during robotic procedures cause more throat pain, hoarseness, or trouble swallowing afterward. Researchers measured tube pressure at key points during surgery and checked patients 2 a…

This study followed nearly 1,000 Japanese men with high-risk prostate cancer that had spread to other parts of the body and had not yet received hormone therapy. Researchers tracked how well standard treatments worked in everyday medical practice, including effects on PSA levels,…

This study looked at insurance records of over 3,000 men aged 65+ with metastatic prostate cancer that still responds to hormone therapy. Researchers wanted to see how long patients stayed on newer hormone drugs like abiraterone, apalutamide, or enzalutamide as part of their usua…

This study looked at 90 men with localized prostate cancer to compare the total cost of robot-assisted prostate removal using the da Vinci system versus traditional open surgery. Researchers tracked all medical expenses over 5 years, including the surgery itself and follow-up car…