New hope for kidney cancer patients with bone spread: drug combo trial launches
NCT ID NCT07043608
First seen Jun 24, 2026 · Last updated Jul 28, 2026 · Updated 4 times
Summary
This phase 2 trial tests a new drug called zanzalintinib, taken as a pill, combined with a bone-strengthening agent for people with advanced kidney cancer that has spread to the bones. The study enrolls 20 participants whose cancer has worsened after 1–3 prior treatments, including immunotherapy. The main goal is to see how many patients have no cancer growth after 12 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Zanzalintinib (a targeted therapy pill) plus a bone-strengthening agent (bisphosphonate or denosumab)
- What this could lead to
- If it works, this could offer a new treatment option for people with kidney cancer that has spread to the bones and has stopped responding to immunotherapy.
- What could go wrong
- This is a small, early-phase trial with only 20 participants, so results may not apply to everyone. The drug may not slow the cancer or could cause side effects like fatigue or bone pain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of California, San Francisco
RECRUITINGSan Francisco, California, 94143, United States
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