Can a cancer drug beat steroids for brain radiation injury?

NCT ID NCT06888817

Recruiting now Disease control Sponsor: The Netherlands Cancer Institute Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 14, 2026 · Updated 3 times

Summary

This study compares bevacizumab (Avastin) to standard steroid treatment (dexamethasone) as the first therapy for people with brain radiation necrosis—a side effect of radiation therapy for brain tumors. About 408 participants with high-grade glioma or brain metastases will be randomly assigned to one of the two treatments. The goal is to see which better improves daily function and reduces symptoms, while also being cost-effective.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Bevacizumab (Avastin)
What this could lead to: If it works, this could provide a more effective and safer first-line treatment for brain radiation necrosis, reducing reliance on steroids and improving quality of life.
What could go wrong: This is a phase 3 trial, but it's open-label (not blinded), which can introduce bias. Bevacizumab also has known risks like bleeding and high blood pressure, and it may not work for everyone.

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Conditions

The condition(s) this trial relates to.

brain cancer glioma malignant glioma metastatic malignant neoplasm in the brain radiation injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN METASTASASES HIGH GRADE GLIOMA (III OR IV) RADIATION EFFECT RADIATION INJURIES RADIATION INJURY RADIATION NECROSIS RADIATION TOXICITY

Contacts and locations

Locations

Amsterdam University Medical Centers, location VUmc and AMC
RECRUITING

Amsterdam, Netherlands
Haaglanden Medical Center
RECRUITING

The Hague, 2262 BA Leidschendam, Netherlands
Leiden University Medical Center
RECRUITING

Leiden, 2333 ZA Leiden, Netherlands
Maastricht University Medical Center+
NOT_YET_RECRUITING

Maastricht, 2669HX Maastricht, Netherlands
Netherlands Cancer Institute - Antoni van Leeuwenhoek
RECRUITING

Amsterdam, 1066 CX Amsterdam, Netherlands
University Medical Center Utrecht
RECRUITING

Utrecht, 3584 CX Utrecht, Netherlands

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