BRAIN METASTASASES

This early-phase trial tests an investigational drug called risvutatug rezetecan (GSK5764227) in 15 people with recurrent grade 4 glioma or brain metastases. The drug is designed to seek out and attack tumor cells while sparing healthy tissue. The study first checks how much drug…

This early-stage study tests two drugs—alpelisib and pembrolizumab—together in people with metastatic breast cancer or melanoma that has spread. The main goal is to find a safe dose and watch for side effects. About 50 adults whose cancer has worsened after standard treatments wi…

This study tests whether the drug bevacizumab works better than standard steroid treatment for people with brain swelling caused by radiation therapy. About 408 adults with brain tumors or high-grade glioma who develop this complication will receive either bevacizumab or dexameth…

This study tests a new radiation approach for people with large brain tumors or surgical cavities. Participants first get 4 daily radiation treatments on a linear accelerator, then a 1-2 week break, followed by a final precise dose using a Gamma Knife machine. The goal is to impr…

This study looks at whether a sample of spinal fluid can find cancer DNA in people whose solid tumors have spread to the brain or spinal lining. Researchers will test 60 adults with different types of cancer spread. The goal is to see if this liquid biopsy method works, not to tr…