BRAIN METASTASASES

This early-stage study is testing the safety and best dose of a two-drug combination (alpelisib and pembrolizumab) for patients with advanced breast cancer or melanoma that has spread. It aims to see if this combo can help control the disease, including in cases where cancer has …

This study is testing a new way to treat large brain tumors that have spread from other cancers. Doctors are combining two different radiation machines over several sessions, with a break in between, hoping to target the tumor more precisely. The goal is to better control the can…

This early-stage trial is testing a new targeted drug called risvutatug rezetecan in people with aggressive, recurrent brain cancers. It aims to see how much of the drug reaches the brain tumor and to check its safety. The study will enroll about 15 people with either recurrent g…

This study aims to find the best first treatment for brain swelling (radiation necrosis) that can occur after radiation therapy for brain tumors or metastases. It will compare a drug called bevacizumab, given by IV every three weeks, against the standard steroid pills (dexamethas…

This study is exploring whether testing spinal fluid can better detect cancer that has spread to the brain or its lining compared to standard blood tests. Researchers will collect spinal fluid and blood from 60 patients with solid tumors, including those with and without brain me…