New combo radiation therapy aims to tame large brain tumors

NCT ID NCT07162246

Recruiting now Disease control Sponsor: Sunnybrook Health Sciences Centre Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests a new way to treat large brain tumors using two different radiation machines. Patients get four daily treatments with a linear accelerator, then a break, followed by one precise Gamma Knife treatment. The goal is to better control tumors while protecting healthy brain tissue. The trial will enroll 60 adults with up to two large brain lesions.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Radiation therapy (Gamma Knife and linear accelerator)
What this could lead to: If successful, this could offer a safer, more effective way to treat large brain tumors, reducing side effects like radiation necrosis.
What could go wrong: This is a small, early-phase trial (60 people) testing a new combination. It may not work better than current methods, and there are still risks of side effects.

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Conditions

The condition(s) this trial relates to.

brain cancer metastatic malignant neoplasm in the brain neoplasm Neurologic Manifestations Silver-Russell syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN (NERVOUS SYSTEM) CANCERS BRAIN METASTASASES SRS

Contacts and locations

Locations

Sunnybrook Health Sciences Centre
RECRUITING

Toronto, Ontario, M4N3M5, Canada

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