The Netherlands Cancer Institute

This study tests a drug called trastuzumab-deruxtecan (T-DXd) in people with HER2-positive breast cancer that has spread to 1-3 distant spots (oligo-metastatic). The goal is to shrink or eliminate all cancer with a year of treatment, including local therapies like surgery or radi…

This phase 1 trial tests a new two-drug combination for people with metastatic colorectal cancer that is microsatellite stable (MSS), a type that typically does not respond to immunotherapy alone. The study combines LB-100, which blocks a protein called PP2A to increase stress si…

This study tests a new approach for advanced ovarian cancer. Patients take a targeted drug (olaparib) for a week before surgery, then receive heated chemotherapy directly in the abdomen during the operation. The goal is to see if this combination is safe and effective. The trial …

This study is testing whether giving a short course of immunotherapy drugs before surgery can improve outcomes for people with early-stage colon cancer. Participants will receive a combination of nivolumab, ipilimumab, and possibly other drugs for about 6 to 12 weeks before their…

This study is testing two immunotherapy drugs, botensilimab and balstilimab, given before surgery to people with resectable solid tumors that are either mismatch repair deficient (dMMR) or proficient (pMMR). The goal is to see if this combination can shrink tumors significantly, …

This study compares bevacizumab (Avastin) to standard steroid treatment (dexamethasone) as the first therapy for people with brain radiation necrosis—a side effect of radiation therapy for brain tumors. About 408 participants with high-grade glioma or brain metastases will be ran…

This study compares two different radiation schedules given before surgery for soft tissue sarcoma. One schedule is 14 sessions over about 3 weeks, and the other is just 5 sessions over about 1 week. The goal is to see if the shorter course causes fewer wound complications after …

This study is for women aged 51 or older whose breast cancer has returned or who have a new cancer in the same breast. The goal is to see if giving a focused, short course of radiation before surgery is safe and effective enough to allow breast-conserving treatment instead of mas…

This study tests whether a shorter, more intense radiation treatment (5 sessions) is better than the standard 20-session approach for men with intermediate- or high-risk prostate cancer that hasn't spread. The goal is to improve cancer control while keeping side effects low. Abou…

This phase 2 trial tests whether giving pembrolizumab (Keytruda) plus chemotherapy (carboplatin and paclitaxel) before surgery can completely eliminate advanced penile cancer in the penis and lymph nodes. About 27 men with resectable, node-positive penile cancer will receive the …

This phase 2 trial tests two immunotherapy drugs, nivolumab and relatlimab, given before surgery for stage II-IIIa bladder cancer. The goal is to see if the combination can eliminate the tumor, allowing patients to keep their bladder instead of having it removed. About 90 partici…

This study tests a new type of PET scan that uses a special tracer (Ga68-PSMA) to see if it can tell the difference between a growing tumor and radiation damage in people with brain metastases from lung cancer, melanoma, or breast cancer. About 100 adults who have had radiation t…

This study tests if a special ultrasound using a contrast agent (Sonazoid) can find sentinel lymph nodes as accurately as the standard radioactive tracer method in people with melanoma, breast cancer, or head & neck cancer. About 91 adults will take part, and the goal is to see i…

This study tests whether injecting a special gel (sodium thiosulfate) into the ear before each round of cisplatin chemotherapy can prevent hearing loss. About 100 adults with head and neck cancer will receive the gel in one ear only, so the treated ear can be compared to the untr…

This study tests whether giving a lower radiation dose to healthy parts of the prostate, while keeping a high dose to visible tumors, can reduce bowel and urinary side effects in men with low or intermediate-risk prostate cancer. Participants will receive two sessions of MRI-guid…

This study follows 100 people with stage III triple-negative breast cancer to see how standard treatments affect their quality of life. Participants fill out questionnaires about their well-being at nine time points and may give blood samples to track cancer DNA. The goal is to l…

This study follows 330 adults with advanced or metastatic GIST who have been on targeted therapy (TKIs) for at least 2 years. Researchers will track quality of life, treatment side effects, and financial burdens over up to 10 years. The goal is to better understand the real-world…

This study looks at whether the phase of a woman's menstrual cycle when she starts chemotherapy affects how well the treatment works for breast cancer. Researchers will collect a blood sample from 100 premenopausal women with triple-negative breast cancer on the day they begin ne…