The Netherlands Cancer Institute

This study tests a drug called trastuzumab-deruxtecan (T-DXd) in people with HER2-positive breast cancer that has spread to 1-5 distant spots (oligo-metastatic). The goal is to shrink or eliminate all cancer with a year of treatment, including local therapies like radiation or su…

This study is testing whether giving a short course of immunotherapy drugs before surgery can help treat early-stage colon cancer. About 353 adults with stage 1-3 colon cancer will receive the treatment for 6-12 weeks before their tumor is removed. The goal is to see if this appr…

This study tests a combination of chemotherapy (carboplatin and paclitaxel) plus an immunotherapy drug (pembrolizumab) in 27 men with advanced penile cancer that has spread to lymph nodes. The goal is to see if this treatment can completely eliminate the cancer before surgery. Pa…

This study tests whether the drug bevacizumab works better than standard steroid treatment for people with brain swelling caused by radiation therapy. About 408 adults with brain tumors or high-grade glioma who develop this complication will receive either bevacizumab or dexameth…

This study tests whether adding a targeted drug (olaparib) to heated chemotherapy during surgery can safely treat advanced ovarian cancer. About 55 adults with stage III ovarian cancer will receive the drug before and during surgery. The goal is to find the best dose and check fo…

This study tests whether giving two immunotherapy drugs (nivolumab with or without relatlimab) before surgery can eliminate bladder cancer completely, allowing some patients to avoid bladder removal. About 90 adults with stage II-IIIa bladder cancer will receive the drugs and the…

This study is for women aged 51 or older whose breast cancer has returned in the same breast or is a new cancer in that breast. It tests whether giving a short, targeted course of radiation before surgery is safe and feasible. The goal is to allow breast-conserving treatment agai…

This study is for adults with soft tissue sarcoma who need radiation before surgery. It compares a standard 14-session radiation schedule to a shorter 5-session schedule. The goal is to see if the shorter course leads to similar wound healing and cancer control, while being more …

This study tests two immunotherapy drugs, botensilimab and balstilimab, given before surgery to people with certain solid tumors that can be removed. The goal is to see if the drugs can shrink or eliminate the tumor before surgery. About 133 adults with either mismatch repair def…

This study tests a new, shorter radiation treatment for men with intermediate- to high-risk prostate cancer. The experimental treatment delivers 5 high-dose radiation sessions with a targeted boost to the tumor, compared to the standard 20 sessions. The goal is to see if the shor…

This study looks at whether a special ultrasound using a contrast agent (Sonazoid) can find the first lymph node where cancer might spread, called the sentinel node, as accurately as the current radioactive method. About 91 adults with melanoma, breast cancer, or head & neck canc…

This study tests a new type of PET scan (Ga68-PSMA) to see if it can tell the difference between a growing tumor and radiation-caused damage in people with brain metastases from lung, melanoma, or breast cancer. About 100 adults who either have new brain metastases or a suspiciou…

This study tests whether injecting a medicine called sodium thiosulfate into the middle ear before each round of cisplatin chemotherapy can prevent hearing loss. About 100 adults with head and neck cancer will receive the injection in one ear only, and the treated ear will be com…

This study tests whether lowering the radiation dose to healthy parts of the prostate can reduce bowel and urinary side effects in men with low- or intermediate-risk prostate cancer. Participants will receive two MRI-guided radiation sessions, with one group getting a uniform hig…

This study follows 330 adults with advanced or metastatic GIST who have been on targeted therapy (TKIs) for at least two years. Researchers will track quality of life, treatment side effects, and financial challenges over up to 10 years. The goal is to better understand what long…

This study looks at whether the phase of a woman's menstrual cycle when she starts chemotherapy affects how well the treatment works for breast cancer. Researchers will collect blood samples and track tumor responses in 100 premenopausal women with triple-negative breast cancer. …

This study follows 100 people with stage III triple-negative breast cancer who are receiving standard chemotherapy before or after surgery. Researchers will collect information from medical records and ask participants to fill out quality-of-life questionnaires on a phone app at …