The Netherlands Cancer Institute

This trial is testing whether the drug trastuzumab-deruxtecan (T-DXd) can cure HER2-positive breast cancer that has spread to only 1-3 distant sites in the body. It will enroll 72 patients who have not received prior treatment for this spread. The goal is to use the drug before a…

This study is testing a treatment plan for men with advanced penile cancer that has spread to nearby lymph nodes. Participants receive a combination of chemotherapy and immunotherapy drugs before surgery, followed by more immunotherapy after surgery. The main goal is to see if th…

This study is testing whether giving two immunotherapy drugs before surgery can shrink bladder tumors enough to avoid removing the bladder entirely. The trial will enroll 90 adults with muscle-invasive bladder cancer who are not receiving standard chemotherapy. Researchers will c…

This study is testing whether doctors can safely lower the radiation dose to healthy parts of the prostate to reduce side effects, while still giving a high dose to visible tumors to control cancer. It compares two approaches in men with low or intermediate-risk prostate cancer. …

This study is testing a two-step treatment for women aged 51+ whose breast cancer has returned in the same breast. Instead of removing the entire breast, doctors first give five quick, targeted radiation treatments to the small area of recurrence. One to two weeks later, surgeons…

This study aims to see if a shorter, more intense radiation schedule (5 treatments) can control prostate cancer as well as or better than the current standard schedule (20 treatments). It will enroll 484 men with intermediate or high-risk prostate cancer. The goal is to improve l…

This study is testing whether giving two immunotherapy drugs (botensilimab and balstilimab) before surgery can help shrink tumors in patients with various types of solid cancers. The goal is to see if this approach leads to less cancer remaining after surgery and better long-term…

This study compares two shorter radiation schedules before surgery for soft tissue sarcoma. Patients will receive either 14 treatments over 3 weeks or just 5 treatments over 1 week before their operation. Researchers want to see if the much shorter 5-treatment approach works as w…

This study is testing whether giving short-term immunotherapy before surgery can help control early-stage colon cancer. Patients receive one of several drug combinations for 6-12 weeks before their tumor is surgically removed. The main goals are to see if the treatment is safe, i…

This study is testing if adding a targeted drug called a PARP inhibitor to a special heated chemotherapy wash given during surgery helps control advanced ovarian, fallopian tube, or peritoneal cancer. It will involve up to 55 patients in the Netherlands. The goal is to see if thi…

This study aims to find the best first treatment for brain swelling (radiation necrosis) that can occur after radiation therapy for brain tumors or metastases. It will compare a drug called bevacizumab, given by IV every three weeks, against the standard steroid pills (dexamethas…

This study is testing a new, non-radioactive method to find the first lymph nodes where cancer might spread. It compares a special contrast-enhanced ultrasound to the current standard method that uses a radioactive dye. The goal is to see if the ultrasound method works just as we…

This trial is testing if a gel injected into the middle ear can prevent hearing loss, a common and often permanent side effect of cisplatin chemotherapy. It involves 100 adults with head and neck cancer. Researchers will inject the gel into one ear before each chemo dose and comp…

This study aims to understand how standard chemotherapy affects the quality of life, side effects, and thinking skills of 100 Dutch patients with stage III triple-negative breast cancer. It does not test a new treatment but closely monitors patients during their usual care, using…

This study aims to understand if the timing of a woman's menstrual cycle affects how well chemotherapy works against breast cancer. Researchers will follow 100 premenopausal women with triple-negative breast cancer who are starting chemotherapy before surgery. They will collect a…