Immunotherapy before surgery shows promise for early colon cancer

NCT ID NCT03026140

Recruiting now Disease control Sponsor: The Netherlands Cancer Institute Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether giving a short course of immunotherapy drugs before surgery can improve outcomes for people with early-stage colon cancer. Participants will receive a combination of nivolumab, ipilimumab, and possibly other drugs for about 6 to 12 weeks before their tumor is removed. The goal is to see if this approach is safe and can reduce the chance of the cancer coming back.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: nivolumab, ipilimumab, celecoxib, and BMS-986253 (anti-IL8)
What this could lead to: If successful, this could lead to a new standard of care using short-term immunotherapy before surgery to reduce the risk of cancer returning in early-stage colon cancer patients.
What could go wrong: This is an early-phase exploratory trial with a small number of participants, so results may not apply to all patients. Immunotherapy can cause serious side effects like inflammation of organs.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colon adenocarcinoma colon carcinoma colonic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLON CARCINOMA

Contacts and locations

Locations

Catharina Ziekenhuis
RECRUITING

Eindhoven, Netherlands
Haga ziekenhuis
NOT_YET_RECRUITING

The Hague, Netherlands
Marieke van de Belt
RECRUITING

Amsterdam, 1066CX, Netherlands
OLVG
RECRUITING

Amsterdam, Netherlands
Spaarne Ziekenhuis
RECRUITING

Haarlem, Netherlands
Tergooi
NOT_YET_RECRUITING

Hilversum, Netherlands

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