Can less radiation to healthy prostate cut side effects?

NCT ID NCT07391982

Recruiting now Symptom relief Sponsor: The Netherlands Cancer Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving a lower radiation dose to healthy parts of the prostate, while keeping a high dose to visible tumors, can reduce bowel and urinary side effects in men with low or intermediate-risk prostate cancer. Participants will receive two sessions of MRI-guided radiotherapy using an MR-Linac. The trial compares a uniform high dose to the whole prostate against a tailored approach that spares healthy tissue.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MRI-guided radiotherapy (MR-Linac)
What this could lead to: If successful, this approach could reduce bowel and urinary side effects from prostate radiotherapy while still controlling cancer.
What could go wrong: This is a small, early-phase study with only 54 participants, so results may not apply to all patients. Lowering the dose could also increase the risk of cancer recurrence.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

adenocarcinoma prostate adenocarcinoma prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROSTATE CANCER (ADENOCARCINOMA)

Contacts and locations

Locations

The Netherlands Cancer Institute
RECRUITING

Amsterdam, 1066CX, Netherlands

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