PROSTATE CANCER (ADENOCARCINOMA)
Clinical trials for PROSTATE CANCER (ADENOCARCINOMA) explained in plain language.
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Sharper radiation aims to zap prostate cancer with fewer side effects
Disease control Recruiting nowThis study tests a new way to give radiation for prostate cancer that adapts to your body shape each day. The goal is to safely give a higher dose to the cancer while protecting nearby organs. About 80 adults with intermediate- or high-risk prostate cancer will receive 5 treatmen…
Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)
Phase: NA • Sponsor: Fox Chase Cancer Center • Aim: Disease control
Last updated May 16, 2026 23:47 UTC
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New hope for Hard-to-Treat prostate cancer: drug combo trial launches
Disease control Recruiting nowThis study tests whether the drug talazoparib, given alone or with enzalutamide, can slow cancer growth in men with a specific type of advanced prostate cancer (metastatic castration-resistant) that has certain gene mutations (HRR) and has already progressed after treatment with …
Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)
Phase: PHASE2 • Sponsor: Prostate Cancer Clinical Trials Consortium • Aim: Disease control
Last updated May 16, 2026 23:38 UTC
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New combo therapy aims to knock out high-risk prostate cancer before surgery
Disease control Recruiting nowThis study tests whether giving a strong, targeted radiation treatment (high-dose brachytherapy) before robotic prostate surgery can safely improve outcomes for men with high-risk prostate cancer. Some patients may also receive short-term hormone therapy based on their cancer's g…
Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)
Phase: PHASE1, PHASE2 • Sponsor: The Methodist Hospital Research Institute • Aim: Disease control
Last updated May 16, 2026 23:37 UTC
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One and done? new prostate cancer radiation trial aims to cut treatment to a single session
Disease control Recruiting nowThis study tests whether a single, precise dose of radiation can safely control prostate cancer in men with intermediate or high-risk disease. About 58 participants will receive one targeted treatment session, along with standard hormone therapy. The goal is to see if this shorte…
Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)
Sponsor: University of Milano Bicocca • Aim: Disease control
Last updated May 16, 2026 23:37 UTC
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New hope for hard-to-treat prostate cancer: drug duo enters trial
Disease control Recruiting nowThis study tests two drugs, SKB264 and KL-A167, together in people with aggressive or neuroendocrine prostate cancer that has stopped responding to hormone therapy. The goal is to see if the combination can shrink tumors or slow the disease. About 28 adults who have already tried…
Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)
Phase: PHASE2 • Sponsor: Tianjin Medical University Second Hospital • Aim: Disease control
Last updated May 15, 2026 11:54 UTC
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New drug combo aims to shrink prostate tumors before surgery
Disease control Recruiting nowThis early-phase trial tests whether giving two drugs (darolutamide and relugolix) before prostate cancer surgery is safe and helps shrink tumors. It involves 30 men with high-risk prostate cancer. The main goal is to see how many patients complete the treatment without serious s…
Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)
Phase: PHASE1 • Sponsor: AdventHealth • Aim: Disease control
Last updated May 15, 2026 11:54 UTC
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Major trial tests best way to boost radiation for prostate cancer
Disease control Recruiting nowThis study compares different ways to give extra radiation to the prostate for men with localized prostate cancer. About 1,200 men will be randomly assigned to standard radiation alone or standard radiation plus a boost using one of three techniques. The goal is to see which appr…
Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)
Phase: PHASE2, PHASE3 • Sponsor: Affidea Nu-med Center of Oncological DIagnostics and Therapy • Aim: Disease control
Last updated May 14, 2026 12:06 UTC
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New hope for tough prostate cancer: early trial of ACE-232 begins
Disease control Recruiting nowThis early-phase study tests a new drug called ACE-232 in about 67 men with a hard-to-treat type of advanced prostate cancer (metastatic castration-resistant prostate cancer). The main goals are to check the drug's safety, find the best dose, and see early signs it might help con…
Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)
Phase: PHASE1 • Sponsor: Acerand Therapeutics (Hong Kong) Limited • Aim: Disease control
Last updated May 14, 2026 12:04 UTC
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Could adding chemo to hormone therapy stop prostate cancer from spreading?
Disease control Recruiting nowThis study is for people with prostate cancer that has spread and is not responding well to standard hormone therapy. It tests whether adding a chemotherapy drug (docetaxel) to the usual treatment can lower the chance of the cancer growing or spreading. About 830 participants wil…
Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)
Phase: PHASE3 • Sponsor: Canadian Cancer Trials Group • Aim: Disease control
Last updated May 14, 2026 12:04 UTC
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Gene therapy plus radiation shows promise in prostate cancer trial
Disease control Recruiting nowThis study tests a new gene therapy (aglatimagene besadenovec) combined with standard radiation in 45 men with intermediate-risk prostate cancer. The goal is to see how the therapy spreads in the body and whether it boosts the immune system against the cancer. Participants receiv…
Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)
Phase: PHASE2 • Sponsor: Candel Therapeutics, Inc. • Aim: Disease control
Last updated May 13, 2026 16:02 UTC
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Prostate cancer radiation gets a daily Tune-Up in new trial
Disease control Recruiting nowThis study tests whether adapting radiation therapy each session based on daily organ changes (like bladder filling) can improve treatment for localized prostate cancer. About 100 men aged 60+ with low- or intermediate-risk prostate cancer will receive stereotactic body radiother…
Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)
Phase: NA • Sponsor: Clinique Sainte Clotilde • Aim: Disease control
Last updated May 13, 2026 16:01 UTC
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Laser zaps prostate tumors, may delay or avoid surgery
Disease control Recruiting nowThis study tests a new, less invasive treatment for men with intermediate-risk prostate cancer. Doctors use a special ultrasound to guide a laser that destroys the tumor. The goal is to see if this procedure is safe and can delay or eliminate the need for more aggressive treatmen…
Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)
Phase: NA • Sponsor: University Health Network, Toronto • Aim: Disease control
Last updated May 13, 2026 15:59 UTC
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New hope for Hard-to-Treat prostate cancer: HLD-0915 trial opens
Disease control Recruiting nowThis early-stage trial tests a new drug called HLD-0915 in men with metastatic castration-resistant prostate cancer (mCRPC) whose cancer has worsened despite prior treatments. The study has two parts: first, finding a safe dose, then testing how well that dose works. About 33 par…
Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)
Phase: PHASE1, PHASE2 • Sponsor: Halda Therapeutics OpCo, Inc. • Aim: Disease control
Last updated May 11, 2026 20:49 UTC
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Gut bacteria may unlock prostate cancer drug resistance
Disease control Recruiting nowThis study tests whether adding dexamethasone or metronidazole (a gut bacteria-targeting antibiotic) can make abiraterone work again in men with metastatic prostate cancer whose disease has stopped responding to the drug. About 58 men will receive one of these combinations for up…
Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)
Phase: PHASE2 • Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins • Aim: Disease control
Last updated May 11, 2026 20:49 UTC
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Smart radiation tailored to prostate patients with urinary issues
Disease control Recruiting nowThis study tests a precise type of radiation therapy (SBRT) that adapts to changes in the prostate each week for men with localized prostate cancer who also have urinary symptoms or an enlarged prostate. The goal is to see if this approach reduces side effects while effectively c…
Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)
Sponsor: University of Zurich • Aim: Disease control
Last updated May 11, 2026 20:38 UTC
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New PET scan may outshine MRI for prostate cancer detection
Diagnosis Recruiting nowThis study compares a special PET scan (68Ga-PSMA-11) with standard MRI to see which better detects prostate cancer in 100 newly diagnosed men who haven't had treatment yet. Participants will receive both scans before their scheduled prostate removal surgery, and results will be …
Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)
Phase: PHASE2, PHASE3 • Sponsor: First Affiliated Hospital of Fujian Medical University • Aim: Diagnosis
Last updated May 16, 2026 23:36 UTC
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New PET scan could outshine MRI for spotting prostate cancer
Diagnosis Recruiting nowThis study is testing a new radioactive tracer called 68Ga-P16-093 to see how well it finds prostate cancer using PET scans. It will compare the results to standard MRI scans in 50 people who have just been diagnosed but haven't started treatment yet. The goal is to see if this n…
Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)
Phase: PHASE1, PHASE2 • Sponsor: First Affiliated Hospital of Fujian Medical University • Aim: Diagnosis
Last updated May 15, 2026 11:57 UTC
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New scan spots hidden prostate cancer when PSA is nearly undetectable
Diagnosis Recruiting nowThis study looks at whether a special PET scan (flotufolastat F 18) can find prostate cancer that has come back in men with very low PSA levels (0.20 ng/mL or less) after their prostate was removed. About 50 men who had surgery for prostate cancer and now have a small rise in PSA…
Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)
Sponsor: Massachusetts General Hospital • Aim: Diagnosis
Last updated May 14, 2026 12:06 UTC
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New imaging probes could spot prostate cancer missed by standard scans
Diagnosis Recruiting nowThis study tests two new imaging probes (68Ga-G21 and 68Ga-G23) that target a protein found on most prostate cancer cells. The goal is to see if these probes can detect and stage prostate cancer better than current scans, especially when standard PSMA PET scans are negative or un…
Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)
Phase: PHASE1, PHASE2 • Sponsor: First Affiliated Hospital of Fujian Medical University • Aim: Diagnosis
Last updated May 14, 2026 12:06 UTC
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Smarter prostate radiation: less dose, fewer side effects?
Symptom relief Recruiting nowThis study tests whether lowering the radiation dose to healthy parts of the prostate can reduce bowel and urinary side effects in men with low- or intermediate-risk prostate cancer. Participants will receive two MRI-guided radiation sessions, with one group getting a uniform hig…
Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)
Phase: NA • Sponsor: The Netherlands Cancer Institute • Aim: Symptom relief
Last updated May 16, 2026 23:52 UTC
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Couples tackle prostate cancer together in new study
Symptom relief Recruiting nowThis study tests an 8-week program where prostate cancer patients and their spouses learn and support each other using weekly topics, a mobile app, and professional guidance. The goal is to improve physical symptoms, emotional well-being, and family resilience. About 60 couples w…
Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)
Phase: NA • Sponsor: National Taipei University of Nursing and Health Sciences • Aim: Symptom relief
Last updated May 16, 2026 23:47 UTC
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Hot flash hope: new drug tested for men on prostate cancer therapy
Symptom relief Recruiting nowThis study tests if fezolinetant, a drug used for hot flashes in women, can reduce hot flashes in men with prostate cancer who are on hormone therapy. About 60 men will take either the drug or a placebo daily for 4 weeks. Researchers will track hot flash frequency, severity, and …
Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)
Phase: PHASE2 • Sponsor: Shehzad Basaria, M.D. • Aim: Symptom relief
Last updated May 11, 2026 20:41 UTC
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PSA after prostate surgery: a crystal ball for cancer spread?
Knowledge-focused Recruiting nowThis study follows 500 men who had their prostate removed for cancer. Researchers check PSA levels soon after surgery to see if they can predict if the cancer will come back or spread. No new treatments are given—just standard care and observation.
Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)
Sponsor: Lithuanian University of Health Sciences • Aim: Knowledge-focused
Last updated May 16, 2026 23:51 UTC
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New study aims to predict prostate cancer treatment success after just one cycle
Knowledge-focused Recruiting nowThis study is for men with advanced prostate cancer that has spread. It tests whether a special scan (dosimetry) after the first treatment cycle can predict if the therapy will work. The goal is to personalize treatment early, avoiding ineffective cycles. About 110 participants w…
Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)
Sponsor: Jules Bordet Institute • Aim: Knowledge-focused
Last updated May 16, 2026 23:46 UTC
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Virtual reality map guides prostate cancer surgery
Knowledge-focused Recruiting nowThis study tests whether a 3D virtual model, created from a special PET scan, can help surgeons more accurately remove lymph nodes that contain prostate cancer. About 100 men with prostate cancer that has spread to a few lymph nodes will take part. The goal is to see if the model…
Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)
Phase: NA • Sponsor: Martini-Klinik am UKE GmbH • Aim: Knowledge-focused
Last updated May 15, 2026 11:57 UTC
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What do men think about breast side effects from prostate cancer treatment?
Knowledge-focused Recruiting nowThis study talks to men with prostate cancer to learn how they feel about the risk of breast-related side effects, like breast growth, from their treatment. The goal is to understand what matters most to them when choosing between cancer control and quality of life. About 24 men …
Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)
Phase: NA • Sponsor: St Vincent's Hospital, Sydney • Aim: Knowledge-focused
Last updated May 12, 2026 13:44 UTC
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New scan may catch returning prostate cancer earlier after focal therapy
Knowledge-focused Recruiting nowThis study looks at whether adding a special scan called PSMA PET to the usual MRI can help find prostate cancer that comes back after focal therapy (a treatment that targets only the tumor). About 62 men who have had focal therapy will get both scans. The goal is to see if the P…
Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)
Phase: NA • Sponsor: University of Chicago • Aim: Knowledge-focused
Last updated May 06, 2026 16:02 UTC
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Massive study launches to map prostate cancer across algeria
Knowledge-focused Recruiting nowThis study aims to understand the real-world picture of prostate cancer in Algeria. Researchers will observe 2,000 patients to learn about their backgrounds, how they were diagnosed, and what treatments they receive. The goal is to gather information to help improve future care, …
Matched conditions: PROSTATE CANCER (ADENOCARCINOMA)
Sponsor: Société Algérienne de Formation et Recherche en Oncologie • Aim: Knowledge-focused
Last updated Apr 07, 2026 14:35 UTC