The Netherlands Cancer Institute

This phase III trial tests whether a personalized, high-dose chemotherapy followed by stem cell rescue can improve cure rates for people with high-risk, BRCA1-like breast cancer. The study includes 174 participants with stage III, HER2-negative tumors. The goal is to see if this …

This study tests a way to make radiation therapy more precise for people with head and neck cancer. Doctors use a special scan (SPECT/CT) to see which lymph nodes drain fluid from the tumor. If the scan shows no drainage to the opposite side of the neck, that side can be safely l…

This study aimed to test a new drug (LY3200882) combined with a standard chemotherapy (capecitabine) in people with advanced colorectal cancer that had stopped responding to previous treatment. The goal was to see if the combination could make the cancer respond again. However, t…

This study tests whether giving immunotherapy before surgery can shrink tumors in people with a type of kidney cancer that is at high risk of coming back. About 69 adults with clear cell renal cell carcinoma will receive one of three drug combinations (nivolumab alone, nivolumab …

This study looks at whether women with a very early, low-risk form of breast cancer called DCIS can be safely monitored with regular mammograms instead of undergoing immediate surgery or radiation. About 2,500 women aged 45 and older with low-grade DCIS will either receive standa…

This study tests the drug pembrolizumab in 25 adults with a specific type of advanced colorectal cancer (dMMR) that cannot be surgically removed. The goal is to see if the drug can shrink tumors enough to allow surgery or avoid it altogether. Participants receive pembrolizumab an…

This study tests whether giving a different immunotherapy drug (ipilimumab) and targeted radiation can make a standard immunotherapy (anti-PD-1) work again for people with advanced non-small cell lung cancer. About 54 participants will receive this combination to see if it shrink…

This study compares a shorter, 3-week course of radiation before surgery to the standard 5-week course for people with soft tissue sarcomas. The goal is to see if the shorter schedule leads to similar wound healing after surgery and keeps the cancer from coming back just as well.…

This study tests whether adding heated chemotherapy directly into the abdomen during surgery helps people with stage III ovarian cancer live longer. About 538 participants are randomly assigned to standard surgery alone or surgery plus the heated chemo. The main goal is to see if…

This study tests a new way to give radiation for prostate cancer that aims to reduce side effects. Instead of giving the same dose to the whole prostate, the tumor gets a higher dose and the rest of the prostate gets a lower dose. The study includes 20 men with intermediate-risk …

This study looks at 304 people with advanced triple negative breast cancer, a hard-to-treat type. Researchers want to see if a genetic test can tell who will do better on one chemo (carboplatin-cyclophosphamide) versus another (paclitaxel), and whether adding the immunotherapy dr…