Breast cancer overdiagnosis? landmark trial tests monitoring vs. surgery for Low-Risk DCIS

NCT ID NCT02492607

Ongoing Disease control Sponsor: The Netherlands Cancer Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether women with a very early, low-risk form of breast cancer called DCIS can safely avoid standard treatments like surgery and radiation. Instead, they would simply get a yearly mammogram to monitor the condition. The goal is to see if this 'active surveillance' approach is as good as standard care at preventing invasive breast cancer over 10 years, while sparing women from unnecessary side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

active surveillance (annual mammography)

What this could lead to

If active surveillance works, many women with low-risk DCIS could avoid surgery or radiation without increasing their risk of invasive breast cancer.

What could go wrong

This is a non-randomized trial, so results may be less reliable. There is a chance that delaying treatment could allow some DCIS to progress to invasive cancer.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

ductal breast carcinoma in situ

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DCIS

Contacts and locations

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Locations

Academisch Ziekenhuis Maastricht

Maastricht, Netherlands
Albert Schweitzer Ziekenhuis

Dordrecht, Netherlands
Alexander Monro Ziekenhuis

Bilthoven, Netherlands
Alrijne Ziekenhuis

Leiderdorp, Netherlands
Amphia Ziekenhuis

Breda, Netherlands
Antonius Ziekenhuis

Sneek, Netherlands
Bernhoven Ziekenhuis

Uden, Netherlands
Canisius-Wilhelmina Ziekenhuis

Nijmegen, Netherlands
Catharina Ziekenhuis

Eindhoven, Netherlands
Deventer Ziekenhuis

Deventer, Netherlands
Diakonessenhuis

Utrecht, Netherlands
Dijklander

Hoorn, Netherlands
Dijklander

Purmerend, Netherlands
Erasmus Medisch Centrum

Rotterdam, Netherlands
Flevoziekenhuis

Almere Stad, Netherlands
Franciscus Gasthuis en Vlietland

Schiedam, Netherlands
Gelre ziekenhuizen

Zutphen, Netherlands
Groene Hart Ziekenhuis

Gouda, Netherlands
Haaglanden MC Antoniushove

Leidschendam, Netherlands
Haga ziekenhuis loc Zoetermeer

Zoetermeer, Netherlands
HagaZiekenhuis

The Hague, Netherlands
Isala Klinieken

Zwolle, Netherlands
Jeroen Bosch Ziekenhuis

's-Hertogenbosch, Netherlands
Leids Universitair Medisch Centrum

Leiden, Netherlands
Maasstad Ziekenhuis

Rotterdam, Netherlands
Martini Ziekenhuis

Groningen, Netherlands
Maxima Medisch Centrum

Eindhoven, Netherlands
Maxima Medisch Centrum - Locatie Veldhoven

Veldhoven, Netherlands
Medisch Centrum Leeuwarden

Leeuwarden, Netherlands
Medisch Spectrum Twente Ariensplain

Enschede, Netherlands
Noordwest Ziekenhuisgroep- site Alkmaar

Alkmaar, Netherlands
Onze Lieve Vrouwe Gasthuis

Amsterdam, Netherlands
Reinier de Graaf Gasthuis

Delft, Netherlands
Rijnstate Ziekenhuis

Arnhem, Netherlands
Rode Kruis Ziekenhuis

Beverwijk, Netherlands
Saxenburgh Medisch Centrum

Hardenberg, Netherlands
Slingeland Ziekenhuis

Doetinchem, Netherlands
Spaarne Gasthuis

Haarlem, Netherlands
Spaarne ziekenhuis

Hoofddorp, Netherlands
St Jans Gasthuis

Weert, Netherlands
St. Antonius Ziekenhuis

Nieuwegein, Netherlands
St. Elisabeth Ziekenhuis

Tilburg, Netherlands
Streekziekenhuis Koningin Beatrix

Winterswijk, Netherlands
Ter Gooi

Hilversum, Netherlands
The Netherlands Cancer Institute-Antoni Van Leeuwenhoekziekenhuis

Amsterdam, Netherlands
Tjongerschans Ziekenhuis

Heerenveen, Netherlands
Treant Zorggroep Bethesda

Hoogeveen, Netherlands
Universitair Medisch Centrum Groningen

Groningen, Netherlands
Universitair Medisch Centrum Utrecht

Utrecht, Netherlands
VieCuri - Medisch Centrum voor Noord-Limburg - Locatie Venlo

Venlo, Netherlands
Wilhelmina Ziekenhuis Assen

Assen, Netherlands
Zaans Medisch Centrum

Zaandam, Netherlands
Ziekenhuis Gelderse Vallei

Ede, Netherlands
Ziekenhuis Rivierenland

Tiel, Netherlands
Ziekenhuis St. Jansdal

Harderwijk, Netherlands
Ziekenhuisgroep Twente

Hengelo, Netherlands
Zorgsaam Zeeuws-Vlaanderen

Terneuzen, Netherlands
Zorgsaam Ziekenhuis

Terneuzen, Netherlands
Zuyderland Medisch Centrum

Heerlen, Netherlands
Zuyderland Ziekenhuis

Sittard, Netherlands