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Breast cancer overdiagnosis? landmark trial tests monitoring vs. surgery for Low-Risk DCIS

NCT ID NCT02492607

Ongoing Disease control Sponsor: The Netherlands Cancer Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether women with a very early, low-risk form of breast cancer called DCIS can safely avoid standard treatments like surgery and radiation. Instead, they would simply get a yearly mammogram to monitor the condition. The goal is to see if this 'active surveillance' approach is as good as standard care at preventing invasive breast cancer over 10 years, while sparing women from unnecessary side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
active surveillance (annual mammography)
What this could lead to
If active surveillance works, many women with low-risk DCIS could avoid surgery or radiation without increasing their risk of invasive breast cancer.
What could go wrong
This is a non-randomized trial, so results may be less reliable. There is a chance that delaying treatment could allow some DCIS to progress to invasive cancer.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

ductal breast carcinoma in situ

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DCIS

Contacts and locations

Locations

  • Academisch Ziekenhuis Maastricht

    Maastricht, Netherlands

  • Albert Schweitzer Ziekenhuis

    Dordrecht, Netherlands

  • Alexander Monro Ziekenhuis

    Bilthoven, Netherlands

  • Alrijne Ziekenhuis

    Leiderdorp, Netherlands

  • Amphia Ziekenhuis

    Breda, Netherlands

  • Antonius Ziekenhuis

    Sneek, Netherlands

  • Bernhoven Ziekenhuis

    Uden, Netherlands

  • Canisius-Wilhelmina Ziekenhuis

    Nijmegen, Netherlands

  • Catharina Ziekenhuis

    Eindhoven, Netherlands

  • Deventer Ziekenhuis

    Deventer, Netherlands

  • Diakonessenhuis

    Utrecht, Netherlands

  • Dijklander

    Hoorn, Netherlands

  • Dijklander

    Purmerend, Netherlands

  • Erasmus Medisch Centrum

    Rotterdam, Netherlands

  • Flevoziekenhuis

    Almere Stad, Netherlands

  • Franciscus Gasthuis en Vlietland

    Schiedam, Netherlands

  • Gelre ziekenhuizen

    Zutphen, Netherlands

  • Groene Hart Ziekenhuis

    Gouda, Netherlands

  • Haaglanden MC Antoniushove

    Leidschendam, Netherlands

  • Haga ziekenhuis loc Zoetermeer

    Zoetermeer, Netherlands

  • HagaZiekenhuis

    The Hague, Netherlands

  • Isala Klinieken

    Zwolle, Netherlands

  • Jeroen Bosch Ziekenhuis

    's-Hertogenbosch, Netherlands

  • Leids Universitair Medisch Centrum

    Leiden, Netherlands

  • Maasstad Ziekenhuis

    Rotterdam, Netherlands

  • Martini Ziekenhuis

    Groningen, Netherlands

  • Maxima Medisch Centrum

    Eindhoven, Netherlands

  • Maxima Medisch Centrum - Locatie Veldhoven

    Veldhoven, Netherlands

  • Medisch Centrum Leeuwarden

    Leeuwarden, Netherlands

  • Medisch Spectrum Twente Ariensplain

    Enschede, Netherlands

  • Noordwest Ziekenhuisgroep- site Alkmaar

    Alkmaar, Netherlands

  • Onze Lieve Vrouwe Gasthuis

    Amsterdam, Netherlands

  • Reinier de Graaf Gasthuis

    Delft, Netherlands

  • Rijnstate Ziekenhuis

    Arnhem, Netherlands

  • Rode Kruis Ziekenhuis

    Beverwijk, Netherlands

  • Saxenburgh Medisch Centrum

    Hardenberg, Netherlands

  • Slingeland Ziekenhuis

    Doetinchem, Netherlands

  • Spaarne Gasthuis

    Haarlem, Netherlands

  • Spaarne ziekenhuis

    Hoofddorp, Netherlands

  • St Jans Gasthuis

    Weert, Netherlands

  • St. Antonius Ziekenhuis

    Nieuwegein, Netherlands

  • St. Elisabeth Ziekenhuis

    Tilburg, Netherlands

  • Streekziekenhuis Koningin Beatrix

    Winterswijk, Netherlands

  • Ter Gooi

    Hilversum, Netherlands

  • The Netherlands Cancer Institute-Antoni Van Leeuwenhoekziekenhuis

    Amsterdam, Netherlands

  • Tjongerschans Ziekenhuis

    Heerenveen, Netherlands

  • Treant Zorggroep Bethesda

    Hoogeveen, Netherlands

  • Universitair Medisch Centrum Groningen

    Groningen, Netherlands

  • Universitair Medisch Centrum Utrecht

    Utrecht, Netherlands

  • VieCuri - Medisch Centrum voor Noord-Limburg - Locatie Venlo

    Venlo, Netherlands

  • Wilhelmina Ziekenhuis Assen

    Assen, Netherlands

  • Zaans Medisch Centrum

    Zaandam, Netherlands

  • Ziekenhuis Gelderse Vallei

    Ede, Netherlands

  • Ziekenhuis Rivierenland

    Tiel, Netherlands

  • Ziekenhuis St. Jansdal

    Harderwijk, Netherlands

  • Ziekenhuisgroep Twente

    Hengelo, Netherlands

  • Zorgsaam Zeeuws-Vlaanderen

    Terneuzen, Netherlands

  • Zorgsaam Ziekenhuis

    Terneuzen, Netherlands

  • Zuyderland Medisch Centrum

    Heerlen, Netherlands

  • Zuyderland Ziekenhuis

    Sittard, Netherlands

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