New test may help tailor treatment for early breast cancer

NCT ID NCT03448926

Recruiting now Knowledge-focused Sponsor: PreludeDx Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is observing how a genetic test called DCISionRT influences treatment decisions for people with ductal carcinoma in situ (DCIS), a very early form of breast cancer. The test predicts the risk of the cancer returning over 10 years and whether radiation therapy would be helpful. Doctors will record their treatment recommendations before and after seeing the test results to see if the test changes their advice. The study involves 3,000 participants and is not testing a new drug or treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could show that using the DCISionRT test helps doctors and patients make more informed, personalized treatment decisions for DCIS, potentially reducing unnecessary treatments.
What could go wrong: This is an observational study, not a treatment trial. It measures changes in recommendations, not patient outcomes. The test's real-world impact on health is not directly assessed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast carcinoma in situ ductal breast carcinoma in situ

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DCIS DUCTAL BREAST CARCINOMA IN SITU STAGE 0 BREAST CANCER

Contacts and locations

Locations

AHN Allegheny General Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15212, United States
Arizona Center for Cancer Care
RECRUITING

Scottsdale, Arizona, 85258, United States
Baptist MD Anderson Cancer Center
RECRUITING

Jacksonville, Florida, 32207, United States
BayCare Health System
RECRUITING

Tampa, Florida, 33607, United States
Baylor College of Medicine
RECRUITING

Houston, Texas, 77030, United States
Cleveland Clinic Akron General
RECRUITING

Akron, Ohio, 44302, United States
Cleveland Clinic Foundation-Taussig Cancer Inst
RECRUITING

Cleveland, Ohio, 44195, United States
Columbia University Medical Center
RECRUITING

New York, New York, 10032, United States
Compass Oncology
RECRUITING

Tigard, Oregon, 97223, United States
Comprehensive Breast Care
RECRUITING

Troy, Michigan, 48098, United States
Corewell Health William Beaumont University Center
RECRUITING

Royal Oak, Michigan, 48073, United States
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02115, United States
Emory University Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30322, United States
Endeavor Health (Northshore)
RECRUITING

Evanston, Illinois, 60201, United States
Maimonides Cancer Center
RECRUITING

Brooklyn, New York, 11220, United States
MedStar Health Research Institute
RECRUITING

Baltimore, Maryland, 21237, United States
NYU - Long Island
RECRUITING

Mineola, New York, 11501, United States
NYU - Manhattan
RECRUITING

New York, New York, 10016, United States
Nashville Breast Center
RECRUITING

Nashville, Tennessee, 37203, United States
Northwell Health Center for Advanced Medicine
RECRUITING

Lake Success, New York, 11042, United States
Sidney Kimmel Comprehensive Cancer Ctr - Jefferson
RECRUITING

Philadelphia, Pennsylvania, 19027, United States
St Luke's University Health Network
RECRUITING

Easton, Pennsylvania, 18045, United States
Sutter Health
RECRUITING

San Mateo, California, 94401, United States
Texas Oncology
RECRUITING

Plano, Texas, 75093, United States
The Ohio State University
RECRUITING

Columbus, Ohio, 43212, United States
UT Southwestern Medical Center
RECRUITING

Dallas, Texas, 75235, United States
University of California San Diego
RECRUITING

La Jolla, California, 92093, United States
University of Colorado Anschutz Medical Campus
RECRUITING

Aurora, Colorado, 80045, United States
University of South Florida
RECRUITING

Tampa, Florida, 33613, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

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