Could a common diabetes drug stop breast cancer before it starts?
NCT ID NCT01905046
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 3 trial tests whether taking metformin for 12 months can reduce abnormal cells in the breast tissue of women at high risk for breast cancer. Participants have conditions like atypical hyperplasia or a strong family history. Researchers compare metformin to a placebo to see if it lowers the chance of developing breast cancer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
metformin (a common diabetes drug)
What this could lead to
If it works, this could show that a safe, inexpensive drug like metformin helps prevent breast cancer in women at high risk.
What could go wrong
This is a small, early-phase trial with only 86 participants, so results may not apply to everyone. Metformin can cause side effects like stomach upset, and it may not reduce cancer risk.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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City of Hope Comprehensive Cancer Center
Duarte, California, 91010, United States
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City of Hope South Pasadena
South Pasadena, California, 91030, United States
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Cotton O'Neil Cancer Center / Stormont Vail Health
Topeka, Kansas, 66606, United States
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Doctor's Hospital of Laredo
Laredo, Texas, 78041, United States
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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Greenville Health System Cancer Institute-Andrews
Greenville, South Carolina, 29601, United States
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Los Angeles County-USC Medical Center
Los Angeles, California, 90033, United States
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M D Anderson Cancer Center
Houston, Texas, 77030, United States
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Mayo Clinic in Rochester
Rochester, Minnesota, 55905, United States
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Mount Sinai Hospital
New York, New York, 10029, United States
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NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, New York, 10032, United States
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Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210, United States
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Prisma Health Cancer Institute - Butternut
Greenville, South Carolina, 29605, United States
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Prisma Health Cancer Institute - Easley
Easley, South Carolina, 29640, United States
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Prisma Health Cancer Institute - Eastside
Greenville, South Carolina, 29615, United States
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Prisma Health Cancer Institute - Faris
Greenville, South Carolina, 29605, United States
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Prisma Health Cancer Institute - Greer
Greer, South Carolina, 29650, United States
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Prisma Health Cancer Institute - Seneca
Seneca, South Carolina, 29672, United States
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Prisma Health Cancer Institute - Spartanburg
Boiling Springs, South Carolina, 29316, United States
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Prisma Health Greenville Memorial Hospital
Greenville, South Carolina, 29605, United States
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Roswell Park Cancer Institute
Buffalo, New York, 14263, United States
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The Christ Hospital
Cincinnati, Ohio, 45219, United States
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The Community Hospital
Munster, Indiana, 46321, United States
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USC / Norris Comprehensive Cancer Center
Los Angeles, California, 90033, United States
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University of Kansas Cancer Center
Kansas City, Kansas, 66160, United States
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University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104, United States
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University of Wisconsin Carbone Cancer Center
Madison, Wisconsin, 53792, United States