Heated chemo during surgery may boost ovarian cancer survival

NCT ID NCT03772028

Ongoing Disease control Sponsor: The Netherlands Cancer Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding heated chemotherapy directly into the abdomen during surgery helps people with stage III ovarian cancer live longer. About 538 participants will be randomly assigned to standard surgery alone or surgery plus the heated chemo. The main goal is to see if the extra treatment improves overall survival and delays cancer return.

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Conditions

The condition(s) this trial relates to.

fallopian tube cancer ovarian cancer ovarian carcinoma primary peritoneal carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OVARIAN CANCER

Contacts and locations

Locations

Alice Bjoernlund-Larsen

Uppsala, Sweden
Amsterdam UMC

Amsterdam, Netherlands
Antoni van leeuwenhoek

Amsterdam, North Holland, 1066CX, Netherlands
CHRU Strasbourg

Strasbourg, France
CHU Lille

Lille, France
CHU Lyon

Lyon, France
CHU de Besancon

Besançon, France
Catharina Hospital

Eindhoven, Netherlands
Centre Leon Berard, Lyon

Lyon, France
City of Hope

Duarte, California, 91010, United States
Erasmus MC

Rotterdam, Netherlands
Fondazione Policlinico A Gemelli IRCCS

Roma, Italy
Institut Bergonié

Bordeaux, France
Institut Curie Paris

Paris, France
Institut de Cancerologie de l'Ouest, ICO Nantes)

Nantes, France
Institut du Cancer Montpellier

Montpellier, France
Leiden University Medical Center (LUMC)

Leiden, Netherlands
MSKCC New York

New York, New York, 10065, United States
Maastricht UMC+

Maastricht, Netherlands
Mater Misericordiae University Hospital, Dublin

Dublin, Ireland
Medisch Spectrum Twente

Enschede, Netherlands
Oncopole, Institute Universitaire du Cancer de Toulouse (IUCT Toulouse)

Toulouse, France
Policlinico Sant'Orsola, Bologna

Bologna, Italy
Radboud MC

Nijmegen, Netherlands
Rigshospitalet Copenhagen

Copenhagen, Denmark
UMCG

Groningen, Netherlands
UMCU

Utrecht, Netherlands
o Institut Bergonié, Bordeaux

Bordeaux, France

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