Could a dual immunotherapy spare the bladder in cancer patients?

NCT ID NCT06237920

First seen Nov 01, 2025 · Last updated May 14, 2026 · Updated 21 times

Summary

This study tests whether giving two immunotherapy drugs (nivolumab with or without relatlimab) before surgery can eliminate bladder cancer completely, allowing some patients to avoid bladder removal. About 90 adults with stage II-IIIa bladder cancer will receive the drugs and then be evaluated for a complete response. The goal is to see if this approach is a safe and effective way to preserve the bladder.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Amsterdam UMC (AUMC)

    RECRUITING

    Amsterdam, North Holland, 1081HV, Netherlands

    Contact

  • Erasmus Medical Center

    RECRUITING

    Rotterdam, Zuid_Holland, 3015GD, Netherlands

    Contact

  • ISALA

    NOT_YET_RECRUITING

    Zwolle, Overijssel, 8025AB, Netherlands

    Contact

  • Leiden University Medical Center (LUMC)

    RECRUITING

    Leiden, South Holland, 2333ZA, Netherlands

    Contact

  • NKI-AVL

    RECRUITING

    Amsterdam, North Holland, 1066CX, Netherlands

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Radboud University Medical Center

    RECRUITING

    Nijmegen, Gelderland, 6525GA, Netherlands

    Contact

  • Rijnstate

    NOT_YET_RECRUITING

    Arnhem, Gelderland, 6815AD, Netherlands

    Contact

  • Spaarne Gasthuis

    RECRUITING

    Hoofddorp, North Holland, 2143TM, Netherlands

    Contact

  • University Medical Center Utrecht

    RECRUITING

    Utrecht, 3584CX, Netherlands

    Contact

Conditions

Explore the condition pages connected to this study.