New MRI scan could reveal hidden clues about brain tumor behavior

NCT ID NCT03324360

Recruiting now Knowledge-focused Sponsor: Sunnybrook Health Sciences Centre Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing a special MRI technique that uses a substance called hyperpolarized 13C-pyruvate to look at how brain metastases (tumors that spread to the brain) use energy. The goal is to see if this scan can help doctors understand which tumors are more likely to resist radiation therapy. About 276 participants will be enrolled to see if the technique is feasible and provides useful information.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Hyperpolarized 13C-Pyruvate injection
What this could lead to: If successful, this imaging technique could help doctors better predict which brain tumors will respond to radiation therapy, allowing more personalized treatment.
What could go wrong: This is a very early phase 1 study focused on feasibility, not treatment. The technique may not prove useful or may not be adopted widely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain cancer metastatic malignant neoplasm in the brain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN METASTASES

Contacts and locations

Locations

Sunnybrook Health Sciences Centre
RECRUITING

Toronto, Ontario, M4N 3M5, Canada

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