MISMATCH REPAIR DEFICIENCY
Clinical trials for MISMATCH REPAIR DEFICIENCY explained in plain language.
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New combo may let some colon cancer patients skip surgery
Disease control Recruiting nowThis study tests two drugs, toripalimab and celecoxib, in people with a specific type of colorectal cancer (dMMR or MSI-H) that has not spread far. The goal is to see if the treatment can make the tumor disappear completely, so some patients might not need surgery. About 105 adul…
Matched conditions: MISMATCH REPAIR DEFICIENCY
Phase: PHASE2 • Sponsor: Sun Yat-sen University • Aim: Disease control
Last updated Jun 27, 2026 12:36 UTC
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New pill-and-immunotherapy cocktail takes on advanced tumors
Disease control Recruiting nowThis study tests an experimental oral drug called Alintegimod (7HP349) combined with two standard immunotherapies (ipilimumab and nivolumab) in people with advanced solid tumors like melanoma, lung, kidney, and liver cancers. The trial has two parts: first, finding a safe dose (p…
Matched conditions: MISMATCH REPAIR DEFICIENCY
Phase: PHASE1, PHASE2 • Sponsor: 7 Hills Pharma, LLC • Aim: Disease control
Last updated Jun 27, 2026 12:06 UTC
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Immunotherapy before surgery may help remove stubborn colon cancer
Disease control Recruiting nowThis trial tests whether giving the immunotherapy drug camrelizumab before surgery can help completely remove T4 colon cancers that have a specific genetic feature (dMMR). These cancers often don't respond well to standard chemotherapy. The study will enroll 18 adults who will re…
Matched conditions: MISMATCH REPAIR DEFICIENCY
Phase: NA • Sponsor: Peking Union Medical College Hospital • Aim: Disease control
Last updated Jun 26, 2026 14:00 UTC
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Blood test could spot colon cancer before it spreads
Diagnosis Recruiting nowThis study is testing a blood test (called a liquid biopsy) to see if it can find colorectal cancer, pre-cancerous growths (adenomas), and cancers linked to Lynch syndrome at an early stage. Researchers will enroll 1,200 people who have already had a colonoscopy. The goal is to s…
Matched conditions: MISMATCH REPAIR DEFICIENCY
Sponsor: San Raffaele University • Aim: Diagnosis
Last updated Jun 27, 2026 09:11 UTC
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AI aims to revolutionize cancer trial enrollment for 50,000 patients
Knowledge-focused Recruiting nowThis study is testing whether an artificial intelligence (AI) tool can help match cancer patients with the right clinical trials. Researchers will enroll up to 50,000 people with various cancers to see if the AI improves trial enrollment rates and patient outcomes. The goal is to…
Matched conditions: MISMATCH REPAIR DEFICIENCY
Sponsor: Massive Bio, Inc. • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:55 UTC