PANCREAS CANCER

This early-stage trial is testing a new oral drug called KESONOTIDE in people with advanced solid tumors that have spread. The main goal is to find a safe dose and see how well the body handles the medicine. About 80 adults with cancers like prostate, breast, lung, ovarian, and o…

This study is for people with advanced pancreas cancer that has spread to only a few other spots in the body. It tests if adding targeted local treatments—like surgery or radiation—to all cancer spots, on top of standard drug therapy, helps control the cancer for a longer time co…

This study is testing whether combining precise radiation therapy with a wearable device that creates electric fields around the tumor can slow the growth of locally advanced pancreatic cancer. All 48 participants will receive five days of targeted radiation while wearing the dev…

This early-stage trial is testing a new oral medication called MOMA-313, given alone or with an existing cancer drug (olaparib), in people with advanced solid tumors that have stopped responding to other treatments. The main goal is to find safe dose levels and see how the body p…

This study is testing whether a special surgical glue can help prevent dangerous fluid leaks after surgery to remove pancreatic or periampullary cancer. About 90 patients having this major operation will be randomly assigned to receive either the glue injection or standard care. …

This study is testing a new three-drug combination (GCN) together with a device that uses electric fields (TTF) to treat metastatic pancreatic cancer. The goal is to see if this combined approach is safe and can help control the cancer for longer. It will involve about 40 adults …

This is the first study in people testing a new cancer drug called MGC026. It aims to find a safe dose and see if the drug can help shrink tumors in adults with advanced solid tumors that have not responded to other treatments. The study will also check how the drug moves through…

This study is testing a shorter, more intense course of targeted radiation therapy for people with locally advanced pancreatic cancer that cannot be surgically removed. It will enroll about 30 patients to see if this approach can better control the tumor in the area where it star…

This study is testing a new experimental drug called CNSI-Fe, which is an iron-loaded nanoparticle suspension injected directly into tumors. The goal is to see if it is safe and can help control cancer in people with advanced solid tumors that have stopped responding to standard …

This study is testing a new radiation therapy approach that uses MRI scans during treatment to adjust radiation beams in real time. Researchers want to see if this method can better target tumors while sparing healthy tissue in patients with various cancers including pancreatic, …

This early-stage study is testing the safety of a new cell therapy for pancreatic cancer that has come back after standard treatment. Doctors modify a patient's own immune cells (called CAR-T cells) to target a protein found on pancreatic cancer cells. The main goal is to find a …

This study is testing whether combining standard chemotherapy with a procedure called irreversible electroporation (IRE) is safe and effective for controlling advanced pancreatic cancer. IRE uses electrical pulses to damage and destroy tumor cells. The trial will enroll about 20 …

This study is testing a new technique during pancreas cancer surgery. Surgeons will inject a medical-grade glue into the remaining pancreas tissue to try to prevent dangerous fluid leaks, which are a common and serious complication. The trial will enroll 30 patients to see if thi…

This study is testing whether adding a special surgical glue to the connection made during pancreas cancer surgery can prevent dangerous fluid leaks. Researchers are comparing the glue method against standard techniques in 100 patients undergoing this complex operation. The goal …

This early-stage trial is testing a new treatment for people with metastatic pancreatic or breast cancer. The goal is to see if a combination of high-dose chemotherapy drugs, vitamins, and the patient's own stem cells is safe and can overcome the cancer's resistance to treatment.…

This study is testing a new treatment for people with advanced pancreatic cancer that cannot be removed by surgery. Doctors take a patient's own immune cells, arm them in the lab to better recognize and attack cancer, and then infuse them back into the patient. The main goals are…

This early-stage study is testing a new type of treatment called CAR-T cell therapy for people with advanced cancers that have a specific marker (CEA) and have stopped responding to standard treatments like chemotherapy. The main goals are to find a safe dose and see if the treat…

This study is testing the safety of a new, non-invasive device called the HistoSonics Edison System. It uses focused ultrasound waves (histotripsy) to destroy pancreatic tumors in patients with advanced cancer who are not candidates for surgery. The goal is to see if this approac…

This study is testing a new type of personalized cell therapy for adults with advanced solid tumors that have come back or spread. The therapy, called Tmod CAR T, is designed to recognize and kill cancer cells while using a built-in safety switch to protect the patient's healthy …

This study is testing a new type of PET scan to see if it can detect and monitor tissue scarring (fibrosis) caused by radiation therapy. It will enroll 72 adults with lung or pancreatic cancer who are scheduled to receive radiation treatment. The goal is to see if this scan can s…

This study aims to develop and test a better way to tell which pancreatic cysts are harmless and which might turn into cancer. Researchers will follow 5,000 adults with pancreatic cysts to see if a new diagnostic model using clinical information, imaging, and biomarkers can more …

This study is testing whether virtual reality (VR) can help reduce pain and improve quality of life for people with gastrointestinal cancers. Researchers will compare three approaches: VR that teaches pain management skills, VR designed to distract from pain, and a basic VR contr…

This large study aims to find better ways to detect pancreatic cancer early in people at high genetic risk. Researchers will collect and analyze pancreatic fluid from 9,000 participants during scheduled endoscopies, looking for biological markers that signal developing cancer. Th…

This study aims to see if analyzing tiny bits of tumor DNA found in blood and stool (called ctDNA) can help doctors better manage treatment for people with cancers of the digestive system, like pancreatic, colon, and bile duct cancer. It will observe 100 patients to see if these …

This study is creating a large registry of people with pancreatic diseases or who are at high risk for pancreatic cancer. Researchers will collect health information and blood samples from participants to learn how family history, genetics, and other factors contribute to disease…

This study collects tumor and normal tissue samples from patients who are already scheduled for a biopsy or surgery for a solid tumor. The goal is to use these samples in research to discover new targets for future cancer therapies. No experimental treatments are given as part of…

This study aims to collect tumor tissue and blood cells from people with advanced solid tumors to prepare for future CAR T-cell therapy. Researchers will analyze the cancer tissue to understand how tumors hide from the immune system and collect participants' own immune cells thro…

This study aims to learn how to detect pancreatic cancer earlier by observing and collecting samples from up to 20,000 people at high risk, such as those with a strong family history or certain genetic changes. Participants will be followed over time, but this is an observational…

This study is testing a blood test that looks for tiny pieces of cancer DNA in people with pancreatic cancer that can be surgically removed. Researchers want to see if the test results are linked to how long patients live without their cancer getting worse. The goal is to gather …

This study aims to learn how radiation therapy changes the environment inside and around tumors in cervical and pancreatic cancer. Researchers will collect tissue samples, blood, and imaging data from 60 patients before, during, and after their standard radiation and chemotherapy…