PANCREAS CANCER

This early-stage study is testing whether adding a new drug called IM156 to standard chemotherapy (gemcitabine and nab-paclitaxel) is safe for people with advanced pancreatic cancer that has spread. Researchers will enroll 19 patients who haven't had previous treatment for their …

This early-stage study is testing whether adding three common cholesterol-lowering drugs to standard chemotherapy is safe and feasible for people with advanced pancreatic cancer. The idea is that by drastically lowering the body's cholesterol, the drugs might 'starve' the fast-gr…

This is the first time a new drug called TORL-2-307-ADC is being tested in people. The main goal is to find a safe dose and see how the body handles it in 163 patients with advanced solid tumors, including stomach and pancreatic cancer. Researchers will also look for early signs …

This study is testing if adding an experimental drug called defactinib to a precise form of radiation therapy (SBRT) can better control advanced pancreatic cancer that cannot be surgically removed. After initial chemotherapy, 42 participants will be assigned to receive either the…

This study is testing a new combination of four drugs for people with metastatic pancreatic cancer who have not yet received any treatment. The main goals are to find the safest and most effective dose of the new drug pair (avutometinib and defactinib) when added to two standard …

This study is testing whether delivering a precise, high dose of radiation directly to the tumor during surgery can help control pancreatic cancer in patients whose tumors involve major blood vessels. Participants first receive 3-6 months of chemotherapy and external radiation, t…

This study is testing whether a supervised exercise program can help people with pancreatic cancer. Sixteen participants will exercise three times per week for six weeks before their cancer treatment. Researchers will track whether participants can stick with the program and how …

This small, early-stage study is exploring whether a guided therapy session using psilocybin (the active compound in 'magic mushrooms') can help reduce severe depression, anxiety, and emotional distress in people with advanced pancreatic, bile duct, or other gastrointestinal canc…

This early study is testing whether ketorolac, a common anti-inflammatory pain medication, can help stabilize or increase weight in people with advanced pancreatic cancer who are experiencing significant weight loss (cachexia). Researchers will give 28 participants ketorolac for …

This study aims to see if creating 3D models from a patient's tumor and analyzing its genetic information can help doctors find more personalized treatments for pancreatic cancer. It will enroll 200 patients in Ontario, either with cancer that can be removed by surgery or with mo…

This study is testing a different way to provide genetic testing to cancer patients. Instead of referring patients to a genetic counselor, doctors themselves order the tests, and counselors then give results by phone. Researchers are measuring how this change affects patient dist…