PANCREAS CANCER

This study tests whether adding three cholesterol-lowering drugs (atorvastatin, ezetimibe, and evolocumab) to standard chemotherapy can slow or stop advanced pancreatic cancer. It involves 3 newly diagnosed adults with inoperable or metastatic pancreatic cancer. The goal is to se…

This early-phase study tests whether using electric pulses to deliver chemotherapy (bleomycin) directly to the surgical site can lower the chance of pancreatic cancer returning after surgery. About 10 to 20 adults with removable pancreatic tumors will receive this treatment. The …

This study tests an experimental drug called 9-ING-41, which blocks a protein (GSK-3β) that helps cancers grow. It is given alone or with chemotherapy to 350 adults with advanced or hard-to-treat cancers like pancreatic, breast, lung, or bone cancer. The goal is to see if the dru…

This early-phase study tests a new oral drug, MOMA-313, alone or with another drug (olaparib) in people with advanced solid tumors that have a specific DNA repair problem (HR deficiency). The main goals are to check safety, find the best dose, and see if the drug shrinks tumors. …

This study tests whether adding a drug called defactinib to targeted radiation therapy can help control advanced pancreatic cancer better than radiation alone. About 42 people with inoperable pancreatic cancer will take part. The goal is to see if the combination slows cancer gro…

This study tests whether adding two experimental drugs (avutometinib and defactinib) to standard chemotherapy can help people with advanced pancreatic cancer that has spread. About 40 adults with untreated metastatic pancreatic cancer will take part. The goal is to see if the com…

This early-phase study tests whether adding a new drug called IM156 to standard chemotherapy (gemcitabine and nab-paclitaxel) is safe for people with advanced pancreatic cancer. About 19 adults with confirmed metastatic disease are participating. The main goal is to check for sid…

This study tests whether giving a precise dose of radiation directly to the tumor during surgery can help people with pancreatic cancer that involves major blood vessels. Participants had already received chemotherapy and standard radiation before the surgery. The main goal is to…

This early-stage study tests a new drug called TORL-2-307-ADC in 163 people with advanced solid tumors, including stomach, pancreas, and esophageal cancers. The main goals are to find a safe dose and check for side effects. Researchers will also see if the drug can shrink tumors …

This early-stage study tests whether a carefully guided psilocybin (magic mushroom) session can help reduce depression and anxiety in people with advanced, incurable gastrointestinal cancers. The study enrolls 24 adults aged 19-85 who live near Omaha, NE, and have a family member…

This study looks at whether a supervised exercise program is safe and practical for people with pancreatic cancer. Sixteen participants will attend exercise sessions before their main treatment. The goal is to see if at least half of them can stick with the program, and to check …

This early-phase study tests whether ketorolac, a nonsteroidal anti-inflammatory drug (NSAID) similar to ibuprofen, is safe and can help stabilize or increase weight in people with advanced pancreatic cancer who are experiencing cachexia (unintended weight loss). About 28 partici…

This study looks at a new approach where cancer doctors offer genetic testing directly to patients with ovarian, prostate, or pancreas cancer, instead of referring them to a genetic counselor. The goal is to see how patients feel about this method and if it changes their distress…

This study looks at 200 people with pancreatic cancer to see if analyzing their tumor's genes and creating mini-tumors in a lab can help doctors choose more effective treatments. Participants provide tissue, blood, and stool samples, and their health information is tracked over t…