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Surgeons try glue to seal pancreas after cancer surgery

NCT ID NCT07132541

Recruiting now Disease control Sponsor: Minia University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This early-phase trial tests whether injecting a medical glue (Histoacryl®) into the pancreas during Whipple surgery can strengthen the connection between the pancreas and intestine and prevent dangerous leaks. The study involves 30 patients with soft pancreases and narrow ducts, who are at higher risk for leaks. Researchers will track how many develop a pancreatic fistula, pancreatitis, or other complications.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
N-butyl-2-cyanoacrylate (Histoacryl®) tissue adhesive
What this could lead to
If this works, it could offer a simple way to lower the risk of pancreatic leaks after Whipple surgery, potentially reducing complications and hospital stays.
What could go wrong
This is a very early phase 1 trial with only 30 patients. The glue may not reduce leaks as hoped, and there are risks of allergic reaction or tissue damage. Success in this small study may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Anastomotic Leak carcinoma of duodenum cholangiocarcinoma malignant pancreatic neoplasm pancreatic neoplasm periampullary adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PANCREAS CANCER PANCREATICODUODENECTOMY PERIAMPULLARY CANCER POSTOPERATIVE PANCREATIC FISTULA

Contacts and locations

Locations

  • Liver and GIT hospital , Minia University

    RECRUITING

    Minya, Minya Governorate, 61519, Egypt

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