Surgeons try glue to seal pancreas after cancer surgery

NCT ID NCT07132541

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This early-phase trial tests whether injecting a medical glue (Histoacryl®) into the pancreas during Whipple surgery can strengthen the connection between the pancreas and intestine and prevent dangerous leaks. The study involves 30 patients with soft pancreases and narrow ducts, who are at higher risk for leaks. Researchers will track how many develop a pancreatic fistula, pancreatitis, or other complications.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

N-butyl-2-cyanoacrylate (Histoacryl®) tissue adhesive

What this could lead to

If this works, it could offer a simple way to lower the risk of pancreatic leaks after Whipple surgery, potentially reducing complications and hospital stays.

What could go wrong

This is a very early phase 1 trial with only 30 patients. The glue may not reduce leaks as hoped, and there are risks of allergic reaction or tissue damage. Success in this small study may not apply to all patients.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Anastomotic Leak carcinoma of duodenum cholangiocarcinoma malignant pancreatic neoplasm pancreatic neoplasm periampullary adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Liver and GIT hospital , Minia University

    RECRUITING

    Minya, Minya Governorate, 61519, Egypt

    Contact Phone: •••-•••-•••• Email: •••••@•••••